MIR6814

Summary

MIR6814 (microRNA 6814, HGNC:50145) is a microRNA gene on chromosome 21q22.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465488 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50145
Approved symbol	MIR6814
Name	microRNA 6814
Location	21q22.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6814
Ensembl gene	ENSG00000275166
Ensembl biotype	miRNA
Entrez	102465488
RNAcentral	URS000075A7D1 — ncRNA, 70 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000622292

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000622292 — 1 exons

Exon	Start	End
ENSE00003738277	41746772	41746841

Expression profiles

Bgee: expression breadth broad, 70 present calls, max score 90.95.

Top tissues by expression

70 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
duodenum	UBERON:0002114	90.95	gold quality
ectocervix	UBERON:0012249	82.97	gold quality
lower esophagus mucosa	UBERON:0035834	80.41	gold quality
esophagus mucosa	UBERON:0002469	79.30	gold quality
esophagus	UBERON:0001043	78.70	gold quality
liver	UBERON:0002107	77.67	gold quality
gall bladder	UBERON:0002110	77.04	gold quality
urinary bladder	UBERON:0001255	76.59	gold quality
vagina	UBERON:0000996	76.48	gold quality
blood	UBERON:0000178	74.41	gold quality
body of stomach	UBERON:0001161	74.22	gold quality
stomach	UBERON:0000945	74.11	gold quality
skin of abdomen	UBERON:0001416	72.65	gold quality
zone of skin	UBERON:0000014	72.19	gold quality
endocervix	UBERON:0000458	72.13	gold quality
endometrium	UBERON:0001295	71.99	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.90	gold quality
islet of Langerhans	UBERON:0000006	71.85	gold quality
skin of leg	UBERON:0001511	71.83	gold quality
pancreas	UBERON:0001264	71.68	gold quality
adult mammalian kidney	UBERON:0000082	71.55	gold quality
right lobe of liver	UBERON:0001114	71.49	gold quality
fundus of stomach	UBERON:0001160	71.47	gold quality
multicellular organism	UBERON:0000468	70.95	gold quality
body of pancreas	UBERON:0001150	70.91	gold quality
ascending aorta	UBERON:0001496	70.65	gold quality
thoracic aorta	UBERON:0001515	70.57	gold quality
kidney	UBERON:0002113	70.55	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	70.00	gold quality
tibial artery	UBERON:0007610	69.60	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.46

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.