MIR6815

Summary

MIR6815 (microRNA 6815, HGNC:50225) is a microRNA gene on chromosome 21q22.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465489 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50225
Approved symbol	MIR6815
Name	microRNA 6815
Location	21q22.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6815
Ensembl gene	ENSG00000275167
Ensembl biotype	miRNA
Entrez	102465489
RNAcentral	URS000075C175 — miRNA, 61 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000611994

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000611994 — 1 exons

Exon	Start	End
ENSE00003717901	45478266	45478326

Expression profiles

Bgee: expression breadth broad, 77 present calls, max score 83.49.

Top tissues by expression

77 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	83.49	gold quality
blood	UBERON:0000178	76.51	gold quality
body of stomach	UBERON:0001161	74.95	gold quality
liver	UBERON:0002107	74.49	gold quality
fundus of stomach	UBERON:0001160	74.38	gold quality
monocyte	CL:0000576	74.37	gold quality
gastrocnemius	UBERON:0001388	73.37	gold quality
stomach	UBERON:0000945	72.96	gold quality
endocervix	UBERON:0000458	72.92	gold quality
tibial artery	UBERON:0007610	72.59	gold quality
popliteal artery	UBERON:0002250	72.56	gold quality
heart left ventricle	UBERON:0002084	72.33	gold quality
prefrontal cortex	UBERON:0000451	72.18	gold quality
right lobe of liver	UBERON:0001114	72.18	gold quality
body of pancreas	UBERON:0001150	71.81	gold quality
calcaneal tendon	UBERON:0003701	71.42	gold quality
left coronary artery	UBERON:0001626	71.38	gold quality
urinary bladder	UBERON:0001255	70.35	gold quality
ectocervix	UBERON:0012249	69.47	gold quality
heart	UBERON:0000948	69.29	gold quality
endometrium	UBERON:0001295	69.18	gold quality
ascending aorta	UBERON:0001496	68.79	gold quality
thoracic aorta	UBERON:0001515	68.72	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.66	gold quality
left adrenal gland cortex	UBERON:0035825	68.63	gold quality
thoracic mammary gland	UBERON:0005200	67.90	gold quality
multicellular organism	UBERON:0000468	67.81	gold quality
transverse colon	UBERON:0001157	67.55	gold quality
Ammon’s horn	UBERON:0001954	67.47	gold quality
lung	UBERON:0002048	67.46	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.21

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.