MIR6816

Summary

MIR6816 (microRNA 6816, HGNC:50256) is a microRNA gene on chromosome 22q11.21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465490 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50256
Approved symbol	MIR6816
Name	microRNA 6816
Location	22q11.21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6816
Ensembl gene	ENSG00000278278
Ensembl biotype	miRNA
Entrez	102465490
RNAcentral	URS000075AEEC — ncRNA, 66 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000620368

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000620368 — 1 exons

Exon	Start	End
ENSE00003731698	20114686	20114751

Expression profiles

Bgee: expression breadth broad, 74 present calls, max score 77.76.

Top tissues by expression

74 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
muscle of leg	UBERON:0001383	77.76	gold quality
adrenal tissue	UBERON:0018303	77.08	gold quality
gastrocnemius	UBERON:0001388	76.31	gold quality
blood	UBERON:0000178	74.57	gold quality
lymph node	UBERON:0000029	73.11	gold quality
heart left ventricle	UBERON:0002084	72.97	gold quality
monocyte	CL:0000576	70.52	gold quality
putamen	UBERON:0001874	70.48	gold quality
stomach	UBERON:0000945	69.38	gold quality
body of stomach	UBERON:0001161	68.59	gold quality
right lung	UBERON:0002167	68.56	gold quality
substantia nigra	UBERON:0002038	68.53	gold quality
urinary bladder	UBERON:0001255	68.44	gold quality
tibial artery	UBERON:0007610	68.16	gold quality
right frontal lobe	UBERON:0002810	67.87	gold quality
right adrenal gland	UBERON:0001233	67.43	gold quality
left coronary artery	UBERON:0001626	67.04	gold quality
liver	UBERON:0002107	66.88	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.78	gold quality
anterior cingulate cortex	UBERON:0009835	66.66	gold quality
lower esophagus mucosa	UBERON:0035834	66.59	gold quality
body of pancreas	UBERON:0001150	66.48	gold quality
right atrium auricular region	UBERON:0006631	66.43	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	66.42	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.42	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.89	gold quality
thoracic aorta	UBERON:0001515	65.87	gold quality
left adrenal gland cortex	UBERON:0035825	65.47	gold quality
esophagus mucosa	UBERON:0002469	65.46	gold quality
ascending aorta	UBERON:0001496	65.37	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.