MIR6817

Summary

MIR6817 (microRNA 6817, HGNC:50112) is a microRNA gene on chromosome 22q11.23.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466198 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50112
Approved symbol	MIR6817
Name	microRNA 6817
Location	22q11.23
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6817
Ensembl gene	ENSG00000277872
Ensembl biotype	miRNA
Entrez	102466198
RNAcentral	URS000075C303 — miRNA, 66 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000615588

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000615588 — 1 exons

Exon	Start	End
ENSE00003726443	25455646	25455711

Expression profiles

Bgee: expression breadth broad, 84 present calls, max score 87.05.

Top tissues by expression

84 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	87.05	gold quality
vermiform appendix	UBERON:0001154	85.11	gold quality
bone marrow	UBERON:0002371	80.46	gold quality
prefrontal cortex	UBERON:0000451	79.81	gold quality
lymph node	UBERON:0000029	78.37	gold quality
blood	UBERON:0000178	76.73	gold quality
monocyte	CL:0000576	76.10	gold quality
muscle of leg	UBERON:0001383	75.62	gold quality
gastrocnemius	UBERON:0001388	74.65	gold quality
islet of Langerhans	UBERON:0000006	72.86	gold quality
left adrenal gland cortex	UBERON:0035825	71.56	gold quality
liver	UBERON:0002107	70.96	gold quality
adrenal gland	UBERON:0002369	70.79	gold quality
heart left ventricle	UBERON:0002084	70.45	gold quality
heart	UBERON:0000948	70.32	gold quality
body of stomach	UBERON:0001161	70.00	gold quality
right atrium auricular region	UBERON:0006631	69.92	gold quality
tibial artery	UBERON:0007610	69.89	gold quality
rectum	UBERON:0001052	69.82	gold quality
body of pancreas	UBERON:0001150	69.81	gold quality
kidney	UBERON:0002113	69.70	gold quality
urinary bladder	UBERON:0001255	69.67	gold quality
lung	UBERON:0002048	69.36	gold quality
ascending aorta	UBERON:0001496	68.80	gold quality
right lobe of liver	UBERON:0001114	68.58	gold quality
substantia nigra	UBERON:0002038	68.32	gold quality
left adrenal gland	UBERON:0001234	68.14	gold quality
endometrium	UBERON:0001295	68.03	gold quality
left coronary artery	UBERON:0001626	67.95	gold quality
thoracic aorta	UBERON:0001515	67.93	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.48

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.