MIR6819

Summary

MIR6819 (microRNA 6819, HGNC:50155) is a microRNA gene on chromosome 22q12.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465491 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50155
Approved symbol	MIR6819
Name	microRNA 6819
Location	22q12.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6819
Ensembl gene	ENSG00000278420
Ensembl biotype	miRNA
Entrez	102465491
RNAcentral	URS000075C497 — ncRNA, 61 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000622122

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000622122 — 1 exons

Exon	Start	End
ENSE00003744183	36286847	36286907

Expression profiles

Bgee: expression breadth ubiquitous, 113 present calls, max score 96.02.

Top tissues by expression

113 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	96.02	gold quality
apex of heart	UBERON:0002098	90.46	gold quality
skeletal muscle tissue	UBERON:0001134	90.32	gold quality
myometrium	UBERON:0001296	90.19	gold quality
duodenum	UBERON:0002114	90.18	gold quality
bone marrow	UBERON:0002371	89.89	gold quality
mucosa of stomach	UBERON:0001199	89.87	gold quality
body of uterus	UBERON:0009853	89.84	gold quality
prostate gland	UBERON:0002367	89.72	gold quality
ascending aorta	UBERON:0001496	89.33	gold quality
spleen	UBERON:0002106	89.16	gold quality
popliteal artery	UBERON:0002250	88.94	gold quality
tibial artery	UBERON:0007610	88.90	gold quality
thoracic aorta	UBERON:0001515	88.64	gold quality
muscle layer of sigmoid colon	UBERON:0035805	88.34	gold quality
subcutaneous adipose tissue	UBERON:0002190	88.09	gold quality
mucosa of transverse colon	UBERON:0004991	87.86	gold quality
adipose tissue	UBERON:0001013	87.79	gold quality
blood	UBERON:0000178	87.78	gold quality
upper lobe of left lung	UBERON:0008952	87.62	gold quality
omental fat pad	UBERON:0010414	87.49	gold quality
fundus of stomach	UBERON:0001160	87.47	gold quality
left coronary artery	UBERON:0001626	87.42	gold quality
vagina	UBERON:0000996	86.93	gold quality
descending thoracic aorta	UBERON:0002345	86.77	gold quality
thoracic mammary gland	UBERON:0005200	86.74	gold quality
metanephros cortex	UBERON:0010533	86.49	gold quality
vermiform appendix	UBERON:0001154	86.32	gold quality
lung	UBERON:0002048	86.11	gold quality
adrenal tissue	UBERON:0018303	86.04	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.