MIR6820

Summary

MIR6820 (microRNA 6820, HGNC:50095) is a microRNA gene on chromosome 22q13.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465492 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50095
Approved symbol	MIR6820
Name	microRNA 6820
Location	22q13.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6820
Ensembl gene	ENSG00000284289
Ensembl biotype	miRNA
Entrez	102465492
RNAcentral	URS000075EDA2 — ncRNA, 62 nt, 7 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000611508

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000611508 — 1 exons

Exon	Start	End
ENSE00003744024	37967563	37967624

Expression profiles

Bgee: expression breadth broad, 74 present calls, max score 78.13.

Top tissues by expression

74 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	78.13	gold quality
prefrontal cortex	UBERON:0000451	77.80	gold quality
apex of heart	UBERON:0002098	77.54	gold quality
blood	UBERON:0000178	75.48	gold quality
muscle of leg	UBERON:0001383	75.15	gold quality
gastrocnemius	UBERON:0001388	74.20	gold quality
heart left ventricle	UBERON:0002084	72.02	gold quality
mucosa of stomach	UBERON:0001199	71.58	gold quality
body of stomach	UBERON:0001161	71.52	gold quality
right lobe of thyroid gland	UBERON:0001119	71.08	gold quality
liver	UBERON:0002107	70.95	gold quality
right adrenal gland cortex	UBERON:0035827	70.14	gold quality
left coronary artery	UBERON:0001626	69.83	gold quality
right lobe of liver	UBERON:0001114	69.77	gold quality
right atrium auricular region	UBERON:0006631	69.66	gold quality
tibial artery	UBERON:0007610	68.98	gold quality
left adrenal gland cortex	UBERON:0035825	68.86	gold quality
left adrenal gland	UBERON:0001234	68.77	gold quality
granulocyte	CL:0000094	68.76	gold quality
left uterine tube	UBERON:0001303	68.29	gold quality
ascending aorta	UBERON:0001496	67.81	gold quality
fallopian tube	UBERON:0003889	67.55	gold quality
endometrium	UBERON:0001295	67.46	gold quality
Ammon’s horn	UBERON:0001954	67.45	gold quality
lower esophagus mucosa	UBERON:0035834	67.38	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.31	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.19	gold quality
saliva-secreting gland	UBERON:0001044	67.18	gold quality
right adrenal gland	UBERON:0001233	67.15	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Circular RNA hsa_circ_0007367 promotes the progression of pancreatic ductal adenocarcinoma by sponging miR-6820-3p and upregulating YAP1 expression. (PMID:36008392)
• circSSPO boosts growth of esophageal squamous cell carcinoma through upregulation of micrRNA-6820-5p-mediated KLK8 and PKD1 expression. (PMID:37812360)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.