MIR6821

Summary

MIR6821 (microRNA 6821, HGNC:49980) is a microRNA gene on chromosome 22q13.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465493 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49980
Approved symbol	MIR6821
Name	microRNA 6821
Location	22q13.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6821
Ensembl gene	ENSG00000276753
Ensembl biotype	miRNA
Entrez	102465493
RNAcentral	URS000075AFFE — miRNA, 74 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000617625

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000617625 — 1 exons

Exon	Start	End
ENSE00003751371	49962866	49962939

Expression profiles

Bgee: expression breadth ubiquitous, 105 present calls, max score 96.08.

Top tissues by expression

105 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	96.08	gold quality
bone marrow	UBERON:0002371	87.98	gold quality
skeletal muscle tissue	UBERON:0001134	86.26	gold quality
duodenum	UBERON:0002114	84.46	gold quality
vermiform appendix	UBERON:0001154	83.84	gold quality
urinary bladder	UBERON:0001255	81.99	gold quality
blood	UBERON:0000178	81.72	gold quality
prefrontal cortex	UBERON:0000451	81.53	gold quality
body of stomach	UBERON:0001161	79.61	gold quality
stomach	UBERON:0000945	79.16	gold quality
muscle of leg	UBERON:0001383	78.82	gold quality
right lobe of liver	UBERON:0001114	78.62	gold quality
gastrocnemius	UBERON:0001388	78.41	gold quality
liver	UBERON:0002107	78.29	gold quality
adult mammalian kidney	UBERON:0000082	78.25	gold quality
placenta	UBERON:0001987	77.05	gold quality
skin of abdomen	UBERON:0001416	76.74	gold quality
metanephros cortex	UBERON:0010533	76.60	gold quality
prostate gland	UBERON:0002367	76.41	gold quality
adrenal tissue	UBERON:0018303	76.14	gold quality
right adrenal gland cortex	UBERON:0035827	76.05	gold quality
zone of skin	UBERON:0000014	75.58	gold quality
left uterine tube	UBERON:0001303	75.52	gold quality
skin of leg	UBERON:0001511	74.68	gold quality
adrenal gland	UBERON:0002369	74.58	gold quality
omental fat pad	UBERON:0010414	74.55	gold quality
right lung	UBERON:0002167	74.51	gold quality
right adrenal gland	UBERON:0001233	74.25	gold quality
left adrenal gland	UBERON:0001234	74.15	gold quality
thoracic mammary gland	UBERON:0005200	74.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.15

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Circulating miR-6821-5p levels and coronary calcification in asymptomatic familial hypercholesterolemia patients. (PMID:38513437)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.