MIR6822

Summary

MIR6822 (microRNA 6822, HGNC:49999) is a microRNA gene on chromosome 3p22.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466743 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49999
Approved symbol	MIR6822
Name	microRNA 6822
Location	3p22.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6822
Ensembl gene	ENSG00000284158
Ensembl biotype	miRNA
Entrez	102466743
RNAcentral	URS000075C613 — ncRNA, 61 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000621888

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000621888 — 1 exons

Exon	Start	End
ENSE00003740575	39138206	39138266

Expression profiles

Bgee: expression breadth broad, 92 present calls, max score 85.66.

Top tissues by expression

92 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	85.66	gold quality
bone marrow	UBERON:0002371	80.07	gold quality
monocyte	CL:0000576	79.56	gold quality
blood	UBERON:0000178	78.12	gold quality
rectum	UBERON:0001052	77.89	gold quality
muscle of leg	UBERON:0001383	74.89	gold quality
placenta	UBERON:0001987	74.88	gold quality
gastrocnemius	UBERON:0001388	74.49	gold quality
fallopian tube	UBERON:0003889	73.42	gold quality
right testis	UBERON:0004534	72.88	gold quality
islet of Langerhans	UBERON:0000006	72.77	gold quality
endometrium	UBERON:0001295	71.84	gold quality
tonsil	UBERON:0002372	71.73	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.37	gold quality
body of stomach	UBERON:0001161	71.08	gold quality
left testis	UBERON:0004533	71.06	gold quality
lymph node	UBERON:0000029	70.96	gold quality
ectocervix	UBERON:0012249	70.88	gold quality
testis	UBERON:0000473	70.87	gold quality
nucleus accumbens	UBERON:0001882	70.74	gold quality
pituitary gland	UBERON:0000007	70.37	gold quality
stomach	UBERON:0000945	70.23	gold quality
fundus of stomach	UBERON:0001160	70.21	gold quality
left uterine tube	UBERON:0001303	69.85	gold quality
body of pancreas	UBERON:0001150	69.81	gold quality
putamen	UBERON:0001874	69.74	gold quality
tibial artery	UBERON:0007610	69.69	gold quality
amygdala	UBERON:0001876	69.62	gold quality
Ammon’s horn	UBERON:0001954	69.55	gold quality
right atrium auricular region	UBERON:0006631	69.51	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.56

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.