MIR6823

Summary

MIR6823 (microRNA 6823, HGNC:49952) is a microRNA gene on chromosome 3p21.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465494 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49952
Approved symbol	MIR6823
Name	microRNA 6823
Location	3p21.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6823
Ensembl gene	ENSG00000278799
Ensembl biotype	miRNA
Entrez	102465494
RNAcentral	URS000075D950 — miRNA, 61 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000622118

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000622118 — 1 exons

Exon	Start	End
ENSE00003728573	48549961	48550021

Expression profiles

Bgee: expression breadth broad, 44 present calls, max score 81.44.

Top tissues by expression

44 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
prefrontal cortex	UBERON:0000451	81.44	gold quality
heart left ventricle	UBERON:0002084	79.58	gold quality
blood	UBERON:0000178	77.15	gold quality
muscle of leg	UBERON:0001383	77.09	gold quality
monocyte	CL:0000576	75.36	gold quality
small intestine Peyer’s patch	UBERON:0003454	74.50	gold quality
gastrocnemius	UBERON:0001388	73.63	gold quality
body of stomach	UBERON:0001161	72.00	gold quality
tibial artery	UBERON:0007610	69.72	gold quality
cerebral cortex	UBERON:0000956	68.30	gold quality
Ammon’s horn	UBERON:0001954	67.83	gold quality
skin of leg	UBERON:0001511	67.35	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.35	gold quality
right atrium auricular region	UBERON:0006631	67.29	gold quality
anterior cingulate cortex	UBERON:0009835	66.84	gold quality
ascending aorta	UBERON:0001496	66.45	gold quality
cerebellar hemisphere	UBERON:0002245	66.34	gold quality
ectocervix	UBERON:0012249	66.27	gold quality
putamen	UBERON:0001874	65.81	gold quality
brain	UBERON:0000955	65.70	gold quality
body of uterus	UBERON:0009853	65.45	gold quality
upper lobe of left lung	UBERON:0008952	65.29	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	64.92	gold quality
esophagus mucosa	UBERON:0002469	64.57	gold quality
nucleus accumbens	UBERON:0001882	64.23	gold quality
skin of abdomen	UBERON:0001416	63.98	gold quality
Brodmann (1909) area 9	UBERON:0013540	63.92	gold quality
caudate nucleus	UBERON:0001873	63.75	gold quality
right hemisphere of cerebellum	UBERON:0014890	63.70	gold quality
muscle layer of sigmoid colon	UBERON:0035805	63.46	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.55

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.