MIR6824

Summary

MIR6824 (microRNA 6824, HGNC:49946) is a microRNA gene on chromosome 3p21.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465495 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49946
Approved symbol	MIR6824
Name	microRNA 6824
Location	3p21.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6824
Ensembl gene	ENSG00000284364
Ensembl biotype	miRNA
Entrez	102465495
RNAcentral	URS000075BA9C — ncRNA, 63 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000611478

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000611478 — 1 exons

Exon	Start	End
ENSE00003734752	48633636	48633698

Expression profiles

Bgee: expression breadth broad, 17 present calls, max score 77.26.

Top tissues by expression

17 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	77.26	gold quality
gastrocnemius	UBERON:0001388	70.72	gold quality
subcutaneous adipose tissue	UBERON:0002190	69.03	gold quality
left lobe of thyroid gland	UBERON:0001120	65.64	gold quality
right atrium auricular region	UBERON:0006631	65.20	gold quality
esophagus mucosa	UBERON:0002469	61.76	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	59.94	gold quality
thoracic mammary gland	UBERON:0005200	56.76	gold quality
substantia nigra	UBERON:0002038	56.01	gold quality
heart left ventricle	UBERON:0002084	54.51	gold quality
lower esophagus muscularis layer	UBERON:0035833	53.98	gold quality
amygdala	UBERON:0001876	49.24	gold quality
tibial artery	UBERON:0007610	48.24	gold quality
omental fat pad	UBERON:0010414	47.59	gold quality
skin of abdomen	UBERON:0001416	45.57	gold quality
pituitary gland	UBERON:0000007	39.56	silver quality
minor salivary gland	UBERON:0001830	38.25	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.