MIR6825

Summary

MIR6825 (microRNA 6825, HGNC:50208) is a microRNA gene on chromosome 3q21.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466199 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50208
Approved symbol	MIR6825
Name	microRNA 6825
Location	3q21.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6825
Ensembl gene	ENSG00000275067
Ensembl biotype	miRNA
Entrez	102466199
RNAcentral	URS000075B4D3 — miRNA, 66 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000618505

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000618505 — 1 exons

Exon	Start	End
ENSE00003748134	127575266	127575331

Expression profiles

Bgee: expression breadth broad, 84 present calls, max score 86.29.

Top tissues by expression

84 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	86.29	gold quality
prefrontal cortex	UBERON:0000451	83.04	gold quality
sural nerve	UBERON:0015488	80.48	gold quality
lower esophagus mucosa	UBERON:0035834	76.45	gold quality
muscle of leg	UBERON:0001383	75.45	gold quality
blood	UBERON:0000178	75.25	gold quality
placenta	UBERON:0001987	74.03	gold quality
gastrocnemius	UBERON:0001388	73.55	gold quality
adult mammalian kidney	UBERON:0000082	72.94	gold quality
granulocyte	CL:0000094	72.55	gold quality
monocyte	CL:0000576	71.80	gold quality
endocervix	UBERON:0000458	71.68	gold quality
heart left ventricle	UBERON:0002084	71.55	gold quality
left coronary artery	UBERON:0001626	70.81	gold quality
heart	UBERON:0000948	70.30	gold quality
body of stomach	UBERON:0001161	69.76	gold quality
adrenal gland	UBERON:0002369	69.76	gold quality
tibial artery	UBERON:0007610	69.60	gold quality
popliteal artery	UBERON:0002250	69.56	gold quality
fundus of stomach	UBERON:0001160	69.24	gold quality
amygdala	UBERON:0001876	69.08	gold quality
left adrenal gland cortex	UBERON:0035825	69.06	gold quality
myometrium	UBERON:0001296	69.04	gold quality
left ovary	UBERON:0002119	68.91	gold quality
body of pancreas	UBERON:0001150	68.56	gold quality
right lobe of liver	UBERON:0001114	68.46	gold quality
right atrium auricular region	UBERON:0006631	68.45	gold quality
kidney	UBERON:0002113	68.43	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.03	gold quality
right hemisphere of cerebellum	UBERON:0014890	67.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.15

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Exosome-derived lnc-HOXB8-1:2 induces tumor-associated macrophage infiltration to promote neuroendocrine differentiated colorectal cancer progression by sponging hsa-miR-6825-5p. (PMID:36030223)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.