MIR6826

Summary

MIR6826 (microRNA 6826, HGNC:50001) is a microRNA gene on chromosome 3q21.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465496 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50001
Approved symbol	MIR6826
Name	microRNA 6826
Location	3q21.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6826
Ensembl gene	ENSG00000278658
Ensembl biotype	miRNA
Entrez	102465496
RNAcentral	URS000075CF9E — miRNA, 98 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000617808

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000617808 — 1 exons

Exon	Start	End
ENSE00003737241	129272146	129272243

Expression profiles

Bgee: expression breadth broad, 92 present calls, max score 78.22.

Top tissues by expression

92 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	78.22	gold quality
monocyte	CL:0000576	77.87	gold quality
fundus of stomach	UBERON:0001160	77.59	gold quality
bone marrow	UBERON:0002371	76.92	gold quality
adrenal tissue	UBERON:0018303	76.35	gold quality
blood	UBERON:0000178	75.29	gold quality
ectocervix	UBERON:0012249	74.14	gold quality
body of pancreas	UBERON:0001150	72.91	gold quality
gastrocnemius	UBERON:0001388	72.72	gold quality
smooth muscle tissue	UBERON:0001135	71.95	gold quality
liver	UBERON:0002107	71.86	gold quality
stomach	UBERON:0000945	71.49	gold quality
islet of Langerhans	UBERON:0000006	71.18	gold quality
prefrontal cortex	UBERON:0000451	71.12	gold quality
ascending aorta	UBERON:0001496	71.03	gold quality
thoracic aorta	UBERON:0001515	71.03	gold quality
right lobe of liver	UBERON:0001114	70.76	gold quality
endometrium	UBERON:0001295	70.62	gold quality
body of stomach	UBERON:0001161	70.61	gold quality
left coronary artery	UBERON:0001626	70.24	gold quality
tibial artery	UBERON:0007610	70.19	gold quality
popliteal artery	UBERON:0002250	70.16	gold quality
right ovary	UBERON:0002118	69.88	gold quality
heart left ventricle	UBERON:0002084	69.73	gold quality
heart	UBERON:0000948	69.60	gold quality
left ovary	UBERON:0002119	69.27	gold quality
body of uterus	UBERON:0009853	69.18	gold quality
myometrium	UBERON:0001296	69.09	gold quality
left uterine tube	UBERON:0001303	68.90	gold quality
Brodmann (1909) area 9	UBERON:0013540	68.80	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.30

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Although further clarification is needed regarding the functions of miR-6826 and miR-6875 and their relationship to immunerelated molecules, plasma miR-6826 and miR-6875 may be useful negative biomarkers for predicting the efficacy of vaccine treatment in colorectal cancer. (PMID:27878288)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.