MIR6828

Summary

MIR6828 (microRNA 6828, HGNC:50057) is a microRNA gene on chromosome 3q26.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465497 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50057
Approved symbol	MIR6828
Name	microRNA 6828
Location	3q26.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6828
Ensembl gene	ENSG00000283474
Ensembl biotype	miRNA
Entrez	102465497
RNAcentral	URS000075E2AD — ncRNA, 60 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636181

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636181 — 1 exons

Exon	Start	End
ENSE00003800569	170423103	170423162

Expression profiles

Bgee: expression breadth broad, 56 present calls, max score 94.75.

Top tissues by expression

56 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
prefrontal cortex	UBERON:0000451	94.75	gold quality
kidney	UBERON:0002113	93.20	gold quality
blood	UBERON:0000178	76.46	gold quality
stomach	UBERON:0000945	73.68	gold quality
Brodmann (1909) area 9	UBERON:0013540	73.57	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	72.86	gold quality
esophagus mucosa	UBERON:0002469	72.52	gold quality
body of pancreas	UBERON:0001150	72.13	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	72.03	gold quality
heart	UBERON:0000948	69.83	gold quality
left lobe of thyroid gland	UBERON:0001120	69.55	gold quality
gastrocnemius	UBERON:0001388	69.51	gold quality
substantia nigra	UBERON:0002038	69.35	gold quality
right atrium auricular region	UBERON:0006631	68.41	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.33	gold quality
body of stomach	UBERON:0001161	67.54	gold quality
Ammon’s horn	UBERON:0001954	67.22	gold quality
left ovary	UBERON:0002119	67.21	gold quality
nucleus accumbens	UBERON:0001882	67.08	gold quality
putamen	UBERON:0001874	66.96	gold quality
ovary	UBERON:0000992	66.92	gold quality
myometrium	UBERON:0001296	66.81	gold quality
left adrenal gland	UBERON:0001234	66.77	gold quality
brain	UBERON:0000955	66.76	gold quality
omental fat pad	UBERON:0010414	66.71	gold quality
transverse colon	UBERON:0001157	66.55	gold quality
mucosa of transverse colon	UBERON:0004991	66.43	gold quality
adipose tissue	UBERON:0001013	66.39	gold quality
prostate gland	UBERON:0002367	66.33	gold quality
amygdala	UBERON:0001876	66.19	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.