MIR6829

Summary

MIR6829 (microRNA 6829, HGNC:50055) is a microRNA gene on chromosome 3q29.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465977 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50055
Approved symbol	MIR6829
Name	microRNA 6829
Location	3q29
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6829
Ensembl gene	ENSG00000276489
Ensembl biotype	miRNA
Entrez	102465977
RNAcentral	URS000075EF95 — ncRNA, 67 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000620375

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000620375 — 1 exons

Exon	Start	End
ENSE00003743811	195882329	195882395

Expression profiles

Bgee: expression breadth broad, 74 present calls, max score 89.62.

Top tissues by expression

74 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	89.62	gold quality
vermiform appendix	UBERON:0001154	86.99	gold quality
bone marrow	UBERON:0002371	82.70	gold quality
lymph node	UBERON:0000029	81.13	gold quality
mucosa of transverse colon	UBERON:0004991	80.62	gold quality
transverse colon	UBERON:0001157	77.07	gold quality
blood	UBERON:0000178	76.61	gold quality
lower esophagus mucosa	UBERON:0035834	76.26	gold quality
colon	UBERON:0001155	75.68	gold quality
urinary bladder	UBERON:0001255	75.50	gold quality
muscle of leg	UBERON:0001383	75.31	gold quality
rectum	UBERON:0001052	74.89	gold quality
right lobe of liver	UBERON:0001114	74.18	gold quality
gastrocnemius	UBERON:0001388	74.08	gold quality
esophagus mucosa	UBERON:0002469	73.55	gold quality
esophagus	UBERON:0001043	73.19	gold quality
monocyte	CL:0000576	72.45	gold quality
substantia nigra	UBERON:0002038	71.67	gold quality
stomach	UBERON:0000945	71.50	gold quality
heart left ventricle	UBERON:0002084	70.69	gold quality
body of stomach	UBERON:0001161	70.38	gold quality
heart	UBERON:0000948	70.33	gold quality
endometrium	UBERON:0001295	70.01	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.92	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	68.89	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.69	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.38	gold quality
body of pancreas	UBERON:0001150	68.06	gold quality
right atrium auricular region	UBERON:0006631	68.06	gold quality
ascending aorta	UBERON:0001496	67.56	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.30

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.