MIR6830

Summary

MIR6830 (microRNA 6830, HGNC:49966) is a microRNA gene on chromosome 5q31.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465498 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49966
Approved symbol	MIR6830
Name	microRNA 6830
Location	5q31.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6830
Ensembl gene	ENSG00000283678
Ensembl biotype	miRNA
Entrez	102465498
RNAcentral	URS000075BE76 — miRNA, 70 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636015

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636015 — 1 exons

Exon	Start	End
ENSE00003792958	132217849	132217918

Expression profiles

Bgee: expression breadth broad, 38 present calls, max score 74.72.

Top tissues by expression

38 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	74.72	gold quality
prefrontal cortex	UBERON:0000451	71.32	gold quality
amygdala	UBERON:0001876	70.21	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.10	gold quality
tibial nerve	UBERON:0001323	69.03	gold quality
small intestine Peyer’s patch	UBERON:0003454	68.46	gold quality
heart	UBERON:0000948	68.31	gold quality
Ammon’s horn	UBERON:0001954	68.17	gold quality
heart left ventricle	UBERON:0002084	67.61	gold quality
ascending aorta	UBERON:0001496	67.53	gold quality
tibial artery	UBERON:0007610	67.51	gold quality
intestine	UBERON:0000160	67.27	gold quality
upper lobe of left lung	UBERON:0008952	66.78	gold quality
skin of abdomen	UBERON:0001416	66.54	gold quality
right atrium auricular region	UBERON:0006631	65.31	gold quality
body of pancreas	UBERON:0001150	64.88	gold quality
transverse colon	UBERON:0001157	64.88	gold quality
myometrium	UBERON:0001296	64.65	gold quality
left coronary artery	UBERON:0001626	64.54	gold quality
minor salivary gland	UBERON:0001830	64.35	gold quality
skin of leg	UBERON:0001511	64.09	gold quality
esophagus mucosa	UBERON:0002469	63.95	gold quality
anterior cingulate cortex	UBERON:0009835	63.81	gold quality
thyroid gland	UBERON:0002046	63.30	gold quality
omental fat pad	UBERON:0010414	63.24	gold quality
cerebellar hemisphere	UBERON:0002245	62.32	gold quality
colon	UBERON:0001155	62.06	gold quality
vagina	UBERON:0000996	61.64	gold quality
lower esophagus muscularis layer	UBERON:0035833	61.24	gold quality
left lobe of thyroid gland	UBERON:0001120	60.48	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.09

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.