MIR6831

Summary

MIR6831 (microRNA 6831, HGNC:49936) is a microRNA gene on chromosome 5q31.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465499 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49936
Approved symbol	MIR6831
Name	microRNA 6831
Location	5q31.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6831
Ensembl gene	ENSG00000283717
Ensembl biotype	miRNA
Entrez	102465499
RNAcentral	URS000075DA8F — miRNA, 81 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000617240

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000617240 — 1 exons

Exon	Start	End
ENSE00003751349	140563671	140563751

Expression profiles

Bgee: expression breadth broad, 36 present calls, max score 82.87.

Top tissues by expression

36 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
duodenum	UBERON:0002114	82.87	gold quality
endometrium	UBERON:0001295	81.21	gold quality
hypothalamus	UBERON:0001898	70.63	gold quality
gastrocnemius	UBERON:0001388	69.99	gold quality
liver	UBERON:0002107	66.72	gold quality
blood	UBERON:0000178	66.64	gold quality
minor salivary gland	UBERON:0001830	66.09	gold quality
smooth muscle tissue	UBERON:0001135	65.84	gold quality
nucleus accumbens	UBERON:0001882	65.43	gold quality
urinary bladder	UBERON:0001255	64.27	gold quality
prefrontal cortex	UBERON:0000451	63.40	gold quality
esophagus mucosa	UBERON:0002469	63.12	gold quality
body of stomach	UBERON:0001161	63.05	gold quality
caudate nucleus	UBERON:0001873	61.65	gold quality
body of uterus	UBERON:0009853	61.24	gold quality
cerebellar hemisphere	UBERON:0002245	61.16	gold quality
putamen	UBERON:0001874	59.90	gold quality
lower esophagus muscularis layer	UBERON:0035833	59.86	gold quality
upper lobe of left lung	UBERON:0008952	59.06	gold quality
spleen	UBERON:0002106	59.04	gold quality
right lobe of liver	UBERON:0001114	58.91	gold quality
muscle layer of sigmoid colon	UBERON:0035805	58.67	gold quality
subcutaneous adipose tissue	UBERON:0002190	57.81	gold quality
omental fat pad	UBERON:0010414	57.18	gold quality
ascending aorta	UBERON:0001496	56.54	gold quality
myometrium	UBERON:0001296	56.20	gold quality
skin of abdomen	UBERON:0001416	55.87	gold quality
skin of leg	UBERON:0001511	55.80	gold quality
right frontal lobe	UBERON:0002810	55.15	gold quality
thoracic mammary gland	UBERON:0005200	53.56	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.