MIR6832

Summary

MIR6832 (microRNA 6832, HGNC:50140) is a microRNA gene on chromosome 6p21.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466745 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50140
Approved symbol	MIR6832
Name	microRNA 6832
Location	6p21.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6832
Ensembl gene	ENSG00000274494
Ensembl biotype	miRNA
Entrez	102466745
RNAcentral	URS000075D347 — ncRNA, 72 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000616110

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000616110 — 1 exons

Exon	Start	End
ENSE00003713669	31633787	31633858

Expression profiles

Bgee: expression breadth ubiquitous, 114 present calls, max score 97.10.

Top tissues by expression

114 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	97.10	gold quality
skeletal muscle tissue	UBERON:0001134	93.88	gold quality
bone marrow	UBERON:0002371	91.96	gold quality
vermiform appendix	UBERON:0001154	89.91	gold quality
apex of heart	UBERON:0002098	88.27	gold quality
fundus of stomach	UBERON:0001160	86.89	gold quality
endometrium	UBERON:0001295	86.28	gold quality
mucosa of transverse colon	UBERON:0004991	85.55	gold quality
right hemisphere of cerebellum	UBERON:0014890	85.04	gold quality
right adrenal gland cortex	UBERON:0035827	84.24	gold quality
right adrenal gland	UBERON:0001233	83.02	gold quality
cerebellar hemisphere	UBERON:0002245	82.97	gold quality
granulocyte	CL:0000094	82.87	gold quality
pituitary gland	UBERON:0000007	82.86	gold quality
left adrenal gland	UBERON:0001234	82.50	gold quality
adrenal gland	UBERON:0002369	82.30	gold quality
left adrenal gland cortex	UBERON:0035825	81.83	gold quality
lymph node	UBERON:0000029	81.82	gold quality
blood	UBERON:0000178	81.17	gold quality
left ovary	UBERON:0002119	80.94	gold quality
right uterine tube	UBERON:0001302	80.93	gold quality
metanephros cortex	UBERON:0010533	80.88	gold quality
testis	UBERON:0000473	80.68	gold quality
right testis	UBERON:0004534	80.45	gold quality
left testis	UBERON:0004533	80.42	gold quality
ovary	UBERON:0000992	80.19	gold quality
placenta	UBERON:0001987	80.17	gold quality
calcaneal tendon	UBERON:0003701	80.17	gold quality
myometrium	UBERON:0001296	80.01	gold quality
right ovary	UBERON:0002118	79.93	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.