MIR6833

Summary

MIR6833 (microRNA 6833, HGNC:50245) is a microRNA gene on chromosome 6p21.32.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465500 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50245
Approved symbol	MIR6833
Name	microRNA 6833
Location	6p21.32
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6833
Ensembl gene	ENSG00000277264
Ensembl biotype	miRNA
Entrez	102465500
RNAcentral	URS000075F0AA — miRNA, 61 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000620680

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000620680 — 1 exons

Exon	Start	End
ENSE00003735505	32179816	32179876

Expression profiles

Bgee: expression breadth broad, 85 present calls, max score 77.08.

Top tissues by expression

85 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	77.08	gold quality
blood	UBERON:0000178	76.11	gold quality
rectum	UBERON:0001052	75.51	gold quality
muscle of leg	UBERON:0001383	75.35	gold quality
gastrocnemius	UBERON:0001388	74.38	gold quality
heart left ventricle	UBERON:0002084	72.42	gold quality
ectocervix	UBERON:0012249	72.38	gold quality
islet of Langerhans	UBERON:0000006	72.20	gold quality
prefrontal cortex	UBERON:0000451	72.18	gold quality
endometrium	UBERON:0001295	72.13	gold quality
gall bladder	UBERON:0002110	71.64	gold quality
heart	UBERON:0000948	71.19	gold quality
body of pancreas	UBERON:0001150	70.98	gold quality
body of stomach	UBERON:0001161	70.85	gold quality
right atrium auricular region	UBERON:0006631	70.34	gold quality
stomach	UBERON:0000945	70.27	gold quality
left adrenal gland cortex	UBERON:0035825	70.23	gold quality
adult mammalian kidney	UBERON:0000082	69.93	gold quality
fundus of stomach	UBERON:0001160	69.87	gold quality
adrenal gland	UBERON:0002369	69.80	gold quality
left adrenal gland	UBERON:0001234	69.67	gold quality
left ovary	UBERON:0002119	69.51	gold quality
putamen	UBERON:0001874	69.30	gold quality
metanephros cortex	UBERON:0010533	69.08	gold quality
subcutaneous adipose tissue	UBERON:0002190	68.86	gold quality
tibial artery	UBERON:0007610	68.71	gold quality
thoracic aorta	UBERON:0001515	68.48	gold quality
liver	UBERON:0002107	68.36	gold quality
right lobe of liver	UBERON:0001114	68.33	gold quality
ascending aorta	UBERON:0001496	68.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.