MIR6834

Summary

MIR6834 (microRNA 6834, HGNC:50108) is a microRNA gene on chromosome 6p21.32.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465501 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50108
Approved symbol	MIR6834
Name	microRNA 6834
Location	6p21.32
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6834
Ensembl gene	ENSG00000284064
Ensembl biotype	miRNA
Entrez	102465501
RNAcentral	URS000075C53F — ncRNA, 81 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000622807

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000622807 — 1 exons

Exon	Start	End
ENSE00003728158	33290245	33290325

Expression profiles

Bgee: expression breadth broad, 39 present calls, max score 74.75.

Top tissues by expression

39 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lymph node	UBERON:0000029	74.75	gold quality
sural nerve	UBERON:0015488	74.32	gold quality
lung	UBERON:0002048	69.32	gold quality
right atrium auricular region	UBERON:0006631	68.30	gold quality
lower esophagus muscularis layer	UBERON:0035833	63.94	gold quality
tibial artery	UBERON:0007610	63.27	gold quality
gastrocnemius	UBERON:0001388	63.08	gold quality
spleen	UBERON:0002106	62.40	gold quality
heart left ventricle	UBERON:0002084	62.25	gold quality
body of stomach	UBERON:0001161	61.09	gold quality
subcutaneous adipose tissue	UBERON:0002190	60.85	gold quality
body of pancreas	UBERON:0001150	60.65	gold quality
caudate nucleus	UBERON:0001873	60.59	gold quality
right ovary	UBERON:0002118	59.60	gold quality
amygdala	UBERON:0001876	59.36	gold quality
minor salivary gland	UBERON:0001830	58.87	gold quality
esophagus mucosa	UBERON:0002469	58.56	gold quality
cerebellar hemisphere	UBERON:0002245	58.03	gold quality
vagina	UBERON:0000996	57.92	gold quality
muscle layer of sigmoid colon	UBERON:0035805	57.14	gold quality
substantia nigra	UBERON:0002038	56.89	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	56.60	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	56.52	gold quality
skin of abdomen	UBERON:0001416	56.23	gold quality
skin of leg	UBERON:0001511	56.18	gold quality
tibial nerve	UBERON:0001323	55.77	gold quality
blood	UBERON:0000178	55.58	gold quality
anterior cingulate cortex	UBERON:0009835	55.35	gold quality
nucleus accumbens	UBERON:0001882	53.60	gold quality
endometrium	UBERON:0001295	52.95	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LncRNA BC200 promotes the development of EBV-associated nasopharyngeal carcinoma by competitively binding to miR-6834-5p to upregulate TYMS expression. (PMID:39179085)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.