MIR6835

Summary

MIR6835 (microRNA 6835, HGNC:49963) is a microRNA gene on chromosome 6p21.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465502 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49963
Approved symbol	MIR6835
Name	microRNA 6835
Location	6p21.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6835
Ensembl gene	ENSG00000276404
Ensembl biotype	miRNA
Entrez	102465502
RNAcentral	URS000075A49E — ncRNA, 64 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000621552

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000621552 — 1 exons

Exon	Start	End
ENSE00003719720	34240673	34240736

Expression profiles

Bgee: expression breadth ubiquitous, 101 present calls, max score 90.80.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0118 / max 5.0320, expressed in 4 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
67344	0.0118	4

Top tissues by expression

101 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	90.80	gold quality
duodenum	UBERON:0002114	90.79	gold quality
lower esophagus mucosa	UBERON:0035834	87.21	gold quality
lymph node	UBERON:0000029	82.20	gold quality
bone marrow	UBERON:0002371	81.95	gold quality
right uterine tube	UBERON:0001302	79.32	gold quality
esophagus mucosa	UBERON:0002469	78.38	gold quality
placenta	UBERON:0001987	78.02	gold quality
blood	UBERON:0000178	76.98	gold quality
monocyte	CL:0000576	76.42	gold quality
esophagus	UBERON:0001043	75.79	gold quality
skin of abdomen	UBERON:0001416	75.79	gold quality
body of stomach	UBERON:0001161	75.63	gold quality
endometrium	UBERON:0001295	75.63	gold quality
stomach	UBERON:0000945	75.62	gold quality
muscle of leg	UBERON:0001383	75.29	gold quality
liver	UBERON:0002107	75.17	gold quality
zone of skin	UBERON:0000014	74.29	gold quality
gall bladder	UBERON:0002110	74.24	gold quality
gastrocnemius	UBERON:0001388	74.17	gold quality
tonsil	UBERON:0002372	74.17	gold quality
fundus of stomach	UBERON:0001160	73.57	gold quality
small intestine	UBERON:0002108	73.50	gold quality
right lobe of liver	UBERON:0001114	73.45	gold quality
skin of leg	UBERON:0001511	73.08	gold quality
small intestine Peyer’s patch	UBERON:0003454	73.04	gold quality
islet of Langerhans	UBERON:0000006	72.93	gold quality
vagina	UBERON:0000996	72.64	gold quality
kidney	UBERON:0002113	72.37	gold quality
transverse colon	UBERON:0001157	72.22	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.30

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.