MIR6836

Summary

MIR6836 (microRNA 6836, HGNC:50067) is a microRNA gene on chromosome 7p22.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465503 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50067
Approved symbol	MIR6836
Name	microRNA 6836
Location	7p22.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6836
Ensembl gene	ENSG00000284047
Ensembl biotype	miRNA
Entrez	102465503
RNAcentral	URS000075E5DA — miRNA, 63 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000617724

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000617724 — 1 exons

Exon	Start	End
ENSE00003730026	2257515	2257577

Expression profiles

Bgee: expression breadth tissue_specific, 4 present calls, max score 70.07.

Top tissues by expression

4 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	70.07	gold quality
right frontal lobe	UBERON:0002810	64.62	gold quality
vagina	UBERON:0000996	62.29	gold quality
cerebellar hemisphere	UBERON:0002245	54.81	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• MiR-6836-3p promotes proliferation of hypertrophic scar fibroblasts by targeting connective tissue growth factor (PMID:30024593)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.