MIR6837

Summary

MIR6837 (microRNA 6837, HGNC:50125) is a microRNA gene on chromosome 7p13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466985 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50125
Approved symbol	MIR6837
Name	microRNA 6837
Location	7p13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6837
Ensembl gene	ENSG00000284067
Ensembl biotype	miRNA
Entrez	102466985
RNAcentral	URS000075BD00 — ncRNA, 64 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000620884

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000620884 — 1 exons

Exon	Start	End
ENSE00003733350	44051766	44051829

Expression profiles

Bgee: expression breadth broad, 27 present calls, max score 76.51.

Top tissues by expression

27 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	76.51	gold quality
gastrocnemius	UBERON:0001388	72.08	gold quality
right hemisphere of cerebellum	UBERON:0014890	67.50	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	65.90	gold quality
substantia nigra	UBERON:0002038	62.82	gold quality
tibial artery	UBERON:0007610	62.43	gold quality
minor salivary gland	UBERON:0001830	61.94	gold quality
left adrenal gland	UBERON:0001234	60.75	gold quality
anterior cingulate cortex	UBERON:0009835	60.27	gold quality
heart left ventricle	UBERON:0002084	60.20	gold quality
skin of abdomen	UBERON:0001416	59.81	gold quality
muscle layer of sigmoid colon	UBERON:0035805	57.67	gold quality
cerebellar hemisphere	UBERON:0002245	56.76	gold quality
skin of leg	UBERON:0001511	55.51	gold quality
omental fat pad	UBERON:0010414	54.52	gold quality
thoracic mammary gland	UBERON:0005200	54.18	gold quality
ascending aorta	UBERON:0001496	53.22	gold quality
nucleus accumbens	UBERON:0001882	52.39	gold quality
body of stomach	UBERON:0001161	52.27	gold quality
lower esophagus muscularis layer	UBERON:0035833	48.49	gold quality
right coronary artery	UBERON:0001625	47.97	gold quality
putamen	UBERON:0001874	47.85	gold quality
amygdala	UBERON:0001876	47.77	gold quality
adult mammalian kidney	UBERON:0000082	46.25	silver quality
small intestine Peyer’s patch	UBERON:0003454	41.58	silver quality
ovary	UBERON:0000992	38.55	silver quality
left lobe of thyroid gland	UBERON:0001120	34.78	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.