MIR6838

Summary

MIR6838 (microRNA 6838, HGNC:50050) is a microRNA gene on chromosome 7p13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465504 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50050
Approved symbol	MIR6838
Name	microRNA 6838
Location	7p13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6838
Ensembl gene	ENSG00000283969
Ensembl biotype	miRNA
Entrez	102465504
RNAcentral	URS000075CE63 — ncRNA, 56 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000611830

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000611830 — 1 exons

Exon	Start	End
ENSE00003747673	44073378	44073433

Expression profiles

Bgee: expression breadth tissue_specific, 10 present calls, max score 75.72.

Top tissues by expression

10 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	75.72	gold quality
muscle of leg	UBERON:0001383	74.29	gold quality
islet of Langerhans	UBERON:0000006	69.33	gold quality
nucleus accumbens	UBERON:0001882	69.05	gold quality
multicellular organism	UBERON:0000468	67.55	gold quality
putamen	UBERON:0001874	66.62	gold quality
gastrocnemius	UBERON:0001388	60.18	gold quality
anterior cingulate cortex	UBERON:0009835	56.95	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	55.89	gold quality
hypothalamus	UBERON:0001898	48.12	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.22

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• the results of the present study indicate that miR-6838-5p suppresses cell proliferation, metastasis and the EMT process in TNBC by targeting WNT3A to inhibit the Wnt pathway, which may provide a new insight into the therapeutic strategies of TNBC. (PMID:31693779)
• miR-6838-5p Affects Cell Growth, Migration, and Invasion by Targeting GPRIN3 via the Wnt/beta-Catenin Signaling Pathway in Gastric Cancer. (PMID:33254176)
• Long Noncoding RNA CERS6-AS1 Accelerates the Proliferation and Migration of Pancreatic Cancer Cells by Sequestering MicroRNA-15a-5p and MicroRNA-6838-5p and Modulating HMGA1. (PMID:33939677)
• Hsa_circ_0008434 regulates USP9X expression by sponging miR-6838-5p to promote gastric cancer growth, migration and invasion. (PMID:34856948)
• MicroRNA-6838-5p suppresses the self-renewal and metastasis of human liver cancer stem cells through downregulating CBX4 expression and inactivating ERK signaling. (PMID:36215729)
• LncRNA CERS6-AS1, sponging miR-6838-5p, promotes proliferation and invasion in cervical carcinoma cells by upregulating FOXP2. (PMID:36444938)
• MYC-activated CERS6-AS1 sponges miR-6838-5p and regulates the expression of RUBCNL in colorectal cancer. (PMID:37130182)
• LncRNA SH3BP5-AS1 promotes hepatocellular carcinoma progression by sponging miR-6838-5p and activation of PTPN4. (PMID:38761175)
• [MiR-6838-5p overexpression inhibits proliferation of breast cancer MCF-7 cells by downregulating DDR1 expression]. (PMID:39505335)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.