MIR6839

Summary

MIR6839 (microRNA 6839, HGNC:49953) is a microRNA gene on chromosome 7q11.21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465505 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49953
Approved symbol	MIR6839
Name	microRNA 6839
Location	7q11.21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6839
Ensembl gene	ENSG00000275667
Ensembl biotype	miRNA
Entrez	102465505
RNAcentral	URS000075BC1C — miRNA, 113 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000620425

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000620425 — 1 exons

Exon	Start	End
ENSE00003744874	64679064	64679176

Expression profiles

Bgee: expression breadth broad, 54 present calls, max score 81.90.

Top tissues by expression

54 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	81.90	gold quality
liver	UBERON:0002107	79.74	gold quality
vermiform appendix	UBERON:0001154	72.65	gold quality
blood	UBERON:0000178	72.18	gold quality
muscle layer of sigmoid colon	UBERON:0035805	71.46	gold quality
heart	UBERON:0000948	71.15	gold quality
tibial artery	UBERON:0007610	71.02	gold quality
heart left ventricle	UBERON:0002084	71.00	gold quality
islet of Langerhans	UBERON:0000006	70.26	gold quality
body of pancreas	UBERON:0001150	69.84	gold quality
ascending aorta	UBERON:0001496	69.61	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.60	gold quality
vagina	UBERON:0000996	68.39	gold quality
thoracic aorta	UBERON:0001515	68.31	gold quality
omental fat pad	UBERON:0010414	68.09	gold quality
hypothalamus	UBERON:0001898	68.05	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.93	gold quality
body of stomach	UBERON:0001161	67.79	gold quality
right hemisphere of cerebellum	UBERON:0014890	67.66	gold quality
skin of abdomen	UBERON:0001416	67.09	gold quality
caudate nucleus	UBERON:0001873	66.76	gold quality
zone of skin	UBERON:0000014	66.65	gold quality
esophagus mucosa	UBERON:0002469	66.50	gold quality
anterior cingulate cortex	UBERON:0009835	66.13	gold quality
skin of leg	UBERON:0001511	66.07	gold quality
endocervix	UBERON:0000458	65.55	gold quality
left ovary	UBERON:0002119	65.53	gold quality
putamen	UBERON:0001874	65.48	gold quality
minor salivary gland	UBERON:0001830	65.33	gold quality
transverse colon	UBERON:0001157	65.31	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• TEAD4 expression is regulated by miR-6839-3p in lung adenocarcinoma . (PMID:29667772)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.