MIR6841

Summary

MIR6841 (microRNA 6841, HGNC:50070) is a microRNA gene on chromosome 8p21.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465506 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50070
Approved symbol	MIR6841
Name	microRNA 6841
Location	8p21.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6841
Ensembl gene	ENSG00000283327
Ensembl biotype	miRNA
Entrez	102465506
RNAcentral	URS000075B664 — ncRNA, 72 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000637129

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000637129 — 1 exons

Exon	Start	End
ENSE00003791849	24953796	24953867

Expression profiles

Bgee: expression breadth broad, 32 present calls, max score 83.96.

Top tissues by expression

32 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	83.96	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	70.80	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.43	gold quality
endometrium	UBERON:0001295	68.46	gold quality
anterior cingulate cortex	UBERON:0009835	67.85	gold quality
ascending aorta	UBERON:0001496	67.31	gold quality
frontal cortex	UBERON:0001870	66.94	gold quality
right frontal lobe	UBERON:0002810	66.85	gold quality
putamen	UBERON:0001874	66.53	gold quality
Ammon’s horn	UBERON:0001954	66.33	gold quality
skin of leg	UBERON:0001511	66.30	gold quality
Brodmann (1909) area 9	UBERON:0013540	65.67	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.49	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.05	gold quality
left coronary artery	UBERON:0001626	64.69	gold quality
vagina	UBERON:0000996	64.46	gold quality
hypothalamus	UBERON:0001898	64.23	gold quality
substantia nigra	UBERON:0002038	64.06	gold quality
cerebellar hemisphere	UBERON:0002245	63.52	gold quality
caudate nucleus	UBERON:0001873	63.51	gold quality
left uterine tube	UBERON:0001303	63.07	gold quality
right hemisphere of cerebellum	UBERON:0014890	62.99	gold quality
tibial nerve	UBERON:0001323	62.85	gold quality
muscle layer of sigmoid colon	UBERON:0035805	62.28	gold quality
nucleus accumbens	UBERON:0001882	61.20	gold quality
small intestine Peyer’s patch	UBERON:0003454	60.37	gold quality
amygdala	UBERON:0001876	59.33	gold quality
pituitary gland	UBERON:0000007	58.14	gold quality
adenohypophysis	UBERON:0002196	54.63	gold quality
right testis	UBERON:0004534	46.78	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.