MIR6842

Summary

MIR6842 (microRNA 6842, HGNC:50254) is a microRNA gene on chromosome 8p21.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465507 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50254
Approved symbol	MIR6842
Name	microRNA 6842
Location	8p21.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6842
Ensembl gene	ENSG00000273836
Ensembl biotype	miRNA
Entrez	102465507
RNAcentral	URS000075E6AB — ncRNA, 65 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000612539

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000612539 — 1 exons

Exon	Start	End
ENSE00003712918	27433370	27433434

Expression profiles

Bgee: expression breadth broad, 57 present calls, max score 80.68.

Top tissues by expression

57 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	80.68	gold quality
blood	UBERON:0000178	78.98	gold quality
prefrontal cortex	UBERON:0000451	77.00	gold quality
gastrocnemius	UBERON:0001388	75.67	gold quality
monocyte	CL:0000576	75.66	gold quality
body of stomach	UBERON:0001161	70.94	gold quality
rectum	UBERON:0001052	70.82	gold quality
ectocervix	UBERON:0012249	70.38	gold quality
right atrium auricular region	UBERON:0006631	69.70	gold quality
myometrium	UBERON:0001296	69.42	gold quality
Ammon’s horn	UBERON:0001954	69.17	gold quality
thoracic aorta	UBERON:0001515	68.14	gold quality
minor salivary gland	UBERON:0001830	68.08	gold quality
ascending aorta	UBERON:0001496	68.00	gold quality
transverse colon	UBERON:0001157	67.52	gold quality
granulocyte	CL:0000094	67.25	gold quality
anterior cingulate cortex	UBERON:0009835	67.22	gold quality
body of pancreas	UBERON:0001150	67.18	gold quality
skin of abdomen	UBERON:0001416	66.85	gold quality
zone of skin	UBERON:0000014	66.84	gold quality
skin of leg	UBERON:0001511	66.62	gold quality
omental fat pad	UBERON:0010414	66.37	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.35	gold quality
thoracic mammary gland	UBERON:0005200	66.09	gold quality
esophagus mucosa	UBERON:0002469	66.04	gold quality
body of uterus	UBERON:0009853	65.99	gold quality
tibial artery	UBERON:0007610	65.68	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.21	gold quality
nucleus accumbens	UBERON:0001882	65.01	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.95	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.57

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.