MIR6843

Summary

MIR6843 (microRNA 6843, HGNC:50240) is a microRNA gene on chromosome 8p21.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465508 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50240
Approved symbol	MIR6843
Name	microRNA 6843
Location	8p21.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6843
Ensembl gene	ENSG00000284280
Ensembl biotype	miRNA
Entrez	102465508
RNAcentral	URS000075A59F — miRNA, 151 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000617673

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000617673 — 1 exons

Exon	Start	End
ENSE00003716230	27610601	27610751

Expression profiles

Bgee: expression breadth broad, 51 present calls, max score 84.88.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 1.5881 / max 330.1095, expressed in 154 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
92488	1.2311	117
92490	0.1553	85
92489	0.1058	18
92491	0.0959	37

Top tissues by expression

51 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	84.88	gold quality
blood	UBERON:0000178	77.19	gold quality
left coronary artery	UBERON:0001626	71.24	gold quality
duodenum	UBERON:0002114	70.17	gold quality
lymph node	UBERON:0000029	69.87	gold quality
bone marrow	UBERON:0002371	67.55	gold quality
kidney	UBERON:0002113	63.79	gold quality
body of pancreas	UBERON:0001150	62.92	gold quality
endocervix	UBERON:0000458	62.76	gold quality
adult mammalian kidney	UBERON:0000082	62.68	gold quality
gall bladder	UBERON:0002110	62.66	gold quality
gastrocnemius	UBERON:0001388	62.49	gold quality
body of uterus	UBERON:0009853	62.13	gold quality
heart left ventricle	UBERON:0002084	61.88	gold quality
ectocervix	UBERON:0012249	61.26	gold quality
tibial artery	UBERON:0007610	60.85	gold quality
small intestine	UBERON:0002108	59.85	gold quality
ascending aorta	UBERON:0001496	59.82	gold quality
upper lobe of left lung	UBERON:0008952	59.34	gold quality
skin of leg	UBERON:0001511	59.13	gold quality
left ovary	UBERON:0002119	59.11	gold quality
body of stomach	UBERON:0001161	59.01	gold quality
skin of abdomen	UBERON:0001416	58.88	gold quality
lung	UBERON:0002048	58.75	gold quality
right atrium auricular region	UBERON:0006631	58.25	gold quality
prostate gland	UBERON:0002367	57.17	gold quality
esophagus mucosa	UBERON:0002469	57.11	gold quality
Brodmann (1909) area 9	UBERON:0013540	57.08	gold quality
stomach	UBERON:0000945	57.04	gold quality
vagina	UBERON:0000996	56.27	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• MicroRNA signature predicts survival in papillary thyroid carcinoma. (PMID:31099134)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.