MIR6845

Summary

MIR6845 (microRNA 6845, HGNC:49956) is a microRNA gene on chromosome 8q24.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466748 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49956
Approved symbol	MIR6845
Name	microRNA 6845
Location	8q24.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6845
Ensembl gene	ENSG00000284142
Ensembl biotype	miRNA
Entrez	102466748
RNAcentral	URS0000759A00 — miRNA, 61 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000613182

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000613182 — 1 exons

Exon	Start	End
ENSE00003745825	143837756	143837816

Expression profiles

Bgee: expression breadth tissue_specific, 8 present calls, max score 98.03.

Top tissues by expression

8 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	98.03	gold quality
blood	UBERON:0000178	74.13	gold quality
muscle of leg	UBERON:0001383	72.86	gold quality
heart left ventricle	UBERON:0002084	71.04	gold quality
gastrocnemius	UBERON:0001388	69.87	gold quality
brain	UBERON:0000955	69.03	gold quality
stomach	UBERON:0000945	65.30	gold quality
prefrontal cortex	UBERON:0000451	60.31	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• hsa-miR-4487 and hsa-miR-6845-3p contributed to the pathogenesis of AD associated with Abeta25-35 mediated by triggering cell apoptosis and synaptic dysfunction (PMID:30547775)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.