MIR6846

Summary

MIR6846 (microRNA 6846, HGNC:50026) is a microRNA gene on chromosome 8q24.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465509 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50026
Approved symbol	MIR6846
Name	microRNA 6846
Location	8q24.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6846
Ensembl gene	ENSG00000277888
Ensembl biotype	miRNA
Entrez	102465509
RNAcentral	URS000075D23C — miRNA, 60 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000613469

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000613469 — 1 exons

Exon	Start	End
ENSE00003713008	144057321	144057380

Expression profiles

Bgee: expression breadth broad, 62 present calls, max score 77.96.

Top tissues by expression

62 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
apex of heart	UBERON:0002098	77.96	gold quality
muscle of leg	UBERON:0001383	75.92	gold quality
blood	UBERON:0000178	75.61	gold quality
gastrocnemius	UBERON:0001388	74.50	gold quality
heart left ventricle	UBERON:0002084	72.63	gold quality
heart	UBERON:0000948	72.35	gold quality
left adrenal gland cortex	UBERON:0035825	71.90	gold quality
right atrium auricular region	UBERON:0006631	70.93	gold quality
tibial artery	UBERON:0007610	70.79	gold quality
right adrenal gland cortex	UBERON:0035827	70.21	gold quality
body of stomach	UBERON:0001161	69.40	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.36	gold quality
stomach	UBERON:0000945	69.00	gold quality
body of pancreas	UBERON:0001150	68.65	gold quality
left adrenal gland	UBERON:0001234	68.24	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.00	gold quality
amygdala	UBERON:0001876	67.83	gold quality
fallopian tube	UBERON:0003889	67.70	gold quality
esophagus	UBERON:0001043	67.62	gold quality
substantia nigra	UBERON:0002038	67.26	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.05	gold quality
right hemisphere of cerebellum	UBERON:0014890	66.99	gold quality
right frontal lobe	UBERON:0002810	66.93	gold quality
anterior cingulate cortex	UBERON:0009835	66.75	gold quality
body of uterus	UBERON:0009853	66.71	gold quality
putamen	UBERON:0001874	66.56	gold quality
Ammon’s horn	UBERON:0001954	66.53	gold quality
esophagus mucosa	UBERON:0002469	66.53	gold quality
transverse colon	UBERON:0001157	66.49	gold quality
left ovary	UBERON:0002119	66.43	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.10

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.