MIR6847

Summary

MIR6847 (microRNA 6847, HGNC:50022) is a microRNA gene on chromosome 8q24.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465510 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50022
Approved symbol	MIR6847
Name	microRNA 6847
Location	8q24.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6847
Ensembl gene	ENSG00000284200
Ensembl biotype	miRNA
Entrez	102465510
RNAcentral	URS000075D9A8 — ncRNA, 69 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000618235

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000618235 — 1 exons

Exon	Start	End
ENSE00003728720	144079874	144079942

Expression profiles

Bgee: expression breadth broad, 18 present calls, max score 69.45.

Top tissues by expression

18 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	69.45	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.88	gold quality
tibial artery	UBERON:0007610	66.32	gold quality
body of pancreas	UBERON:0001150	65.64	gold quality
heart left ventricle	UBERON:0002084	63.50	gold quality
muscle layer of sigmoid colon	UBERON:0035805	61.15	gold quality
omental fat pad	UBERON:0010414	59.70	gold quality
subcutaneous adipose tissue	UBERON:0002190	58.87	gold quality
ectocervix	UBERON:0012249	58.35	gold quality
right hemisphere of cerebellum	UBERON:0014890	52.71	gold quality
esophagus mucosa	UBERON:0002469	52.12	gold quality
transverse colon	UBERON:0001157	49.49	gold quality
skin of abdomen	UBERON:0001416	48.69	gold quality
thyroid gland	UBERON:0002046	48.33	gold quality
skin of leg	UBERON:0001511	47.58	gold quality
minor salivary gland	UBERON:0001830	46.98	gold quality
pituitary gland	UBERON:0000007	45.82	gold quality
tibial nerve	UBERON:0001323	39.59	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.