MIR6848

Summary

MIR6848 (microRNA 6848, HGNC:50176) is a microRNA gene on chromosome 8q24.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465511 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50176
Approved symbol	MIR6848
Name	microRNA 6848
Location	8q24.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6848
Ensembl gene	ENSG00000284229
Ensembl biotype	miRNA
Entrez	102465511
RNAcentral	URS000075C124 — miRNA, 70 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000611213

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000611213 — 1 exons

Exon	Start	End
ENSE00003753687	144317246	144317315

Expression profiles

Bgee: expression breadth broad, 97 present calls, max score 88.06.

Top tissues by expression

97 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
duodenum	UBERON:0002114	88.06	gold quality
vermiform appendix	UBERON:0001154	84.60	gold quality
adrenal tissue	UBERON:0018303	80.92	gold quality
monocyte	CL:0000576	78.24	gold quality
right coronary artery	UBERON:0001625	78.23	gold quality
small intestine	UBERON:0002108	77.73	gold quality
lymph node	UBERON:0000029	77.47	gold quality
blood	UBERON:0000178	76.42	gold quality
small intestine Peyer’s patch	UBERON:0003454	76.25	gold quality
left adrenal gland cortex	UBERON:0035825	75.32	gold quality
adrenal gland	UBERON:0002369	74.90	gold quality
leukocyte	CL:0000738	74.87	gold quality
mucosa of transverse colon	UBERON:0004991	74.56	gold quality
right adrenal gland	UBERON:0001233	74.52	gold quality
muscle of leg	UBERON:0001383	73.99	gold quality
placenta	UBERON:0001987	73.84	gold quality
gastrocnemius	UBERON:0001388	73.82	gold quality
left adrenal gland	UBERON:0001234	73.74	gold quality
intestine	UBERON:0000160	73.41	gold quality
heart left ventricle	UBERON:0002084	72.72	gold quality
transverse colon	UBERON:0001157	72.38	gold quality
lower esophagus mucosa	UBERON:0035834	72.31	gold quality
right adrenal gland cortex	UBERON:0035827	72.23	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.84	gold quality
heart	UBERON:0000948	71.47	gold quality
prefrontal cortex	UBERON:0000451	71.32	gold quality
colon	UBERON:0001155	71.21	gold quality
right atrium auricular region	UBERON:0006631	70.04	gold quality
body of stomach	UBERON:0001161	69.89	gold quality
adult mammalian kidney	UBERON:0000082	69.77	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• CircRNA 06209 inhibits cataract development by sponging miR-6848-5p and regulating ALOX15 expression. (PMID:37673368)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.