MIR6849

Summary

MIR6849 (microRNA 6849, HGNC:49991) is a microRNA gene on chromosome 8q24.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466749 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49991
Approved symbol	MIR6849
Name	microRNA 6849
Location	8q24.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6849
Ensembl gene	ENSG00000283770
Ensembl biotype	miRNA
Entrez	102466749
RNAcentral	URS000075E2F8 — miRNA, 69 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000618543

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000618543 — 1 exons

Exon	Start	End
ENSE00003749184	144400277	144400345

Expression profiles

Bgee: expression breadth broad, 29 present calls, max score 74.18.

Top tissues by expression

29 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart left ventricle	UBERON:0002084	74.18	gold quality
right atrium auricular region	UBERON:0006631	73.16	gold quality
stomach	UBERON:0000945	71.53	gold quality
nucleus accumbens	UBERON:0001882	71.23	gold quality
gastrocnemius	UBERON:0001388	67.70	gold quality
right frontal lobe	UBERON:0002810	65.80	gold quality
body of stomach	UBERON:0001161	65.62	gold quality
omental fat pad	UBERON:0010414	64.50	gold quality
tibial artery	UBERON:0007610	64.20	gold quality
blood	UBERON:0000178	64.15	gold quality
left adrenal gland	UBERON:0001234	62.70	gold quality
hypothalamus	UBERON:0001898	62.13	gold quality
putamen	UBERON:0001874	59.15	gold quality
ascending aorta	UBERON:0001496	59.07	gold quality
cerebellar hemisphere	UBERON:0002245	57.95	gold quality
muscle layer of sigmoid colon	UBERON:0035805	57.41	gold quality
Ammon’s horn	UBERON:0001954	57.03	gold quality
left ovary	UBERON:0002119	56.32	gold quality
spleen	UBERON:0002106	55.26	gold quality
left lobe of thyroid gland	UBERON:0001120	54.71	gold quality
skin of leg	UBERON:0001511	53.83	gold quality
thyroid gland	UBERON:0002046	53.59	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	52.77	gold quality
transverse colon	UBERON:0001157	52.74	gold quality
small intestine Peyer’s patch	UBERON:0003454	50.94	gold quality
skin of abdomen	UBERON:0001416	49.12	gold quality
tibial nerve	UBERON:0001323	48.42	gold quality
left testis	UBERON:0004533	46.83	gold quality
prostate gland	UBERON:0002367	45.70	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.