MIR6850

Summary

MIR6850 (microRNA 6850, HGNC:50093) is a microRNA gene on chromosome 8q24.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465978 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50093
Approved symbol	MIR6850
Name	microRNA 6850
Location	8q24.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6850
Ensembl gene	ENSG00000283764
Ensembl biotype	miRNA
Entrez	102465978
RNAcentral	URS000075D78F — miRNA, 61 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000612162

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000612162 — 1 exons

Exon	Start	End
ENSE00003737333	144791931	144791991

Expression profiles

Bgee: expression breadth broad, 58 present calls, max score 83.98.

Top tissues by expression

58 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	83.98	gold quality
duodenum	UBERON:0002114	83.68	gold quality
monocyte	CL:0000576	75.73	gold quality
muscle of leg	UBERON:0001383	75.73	gold quality
gastrocnemius	UBERON:0001388	74.97	gold quality
blood	UBERON:0000178	72.25	gold quality
heart left ventricle	UBERON:0002084	71.70	gold quality
apex of heart	UBERON:0002098	71.49	gold quality
right atrium auricular region	UBERON:0006631	71.27	gold quality
tibial artery	UBERON:0007610	69.66	gold quality
left adrenal gland	UBERON:0001234	69.42	gold quality
body of stomach	UBERON:0001161	68.98	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.88	gold quality
thoracic aorta	UBERON:0001515	68.65	gold quality
ascending aorta	UBERON:0001496	67.93	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.20	gold quality
adrenal gland	UBERON:0002369	66.95	gold quality
hypothalamus	UBERON:0001898	66.93	gold quality
transverse colon	UBERON:0001157	66.81	gold quality
myometrium	UBERON:0001296	66.64	gold quality
left adrenal gland cortex	UBERON:0035825	66.15	gold quality
upper lobe of left lung	UBERON:0008952	65.69	gold quality
minor salivary gland	UBERON:0001830	65.63	gold quality
thoracic mammary gland	UBERON:0005200	65.55	gold quality
omental fat pad	UBERON:0010414	65.47	gold quality
tibial nerve	UBERON:0001323	65.26	gold quality
skin of abdomen	UBERON:0001416	65.26	gold quality
skin of leg	UBERON:0001511	65.25	gold quality
putamen	UBERON:0001874	65.23	gold quality
adipose tissue	UBERON:0001013	65.19	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Extracellular microRNA profiling for prognostic prediction in patients with high-grade serous ovarian carcinoma. (PMID:34618992)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.