MIR6851

Summary

MIR6851 (microRNA 6851, HGNC:50083) is a microRNA gene on chromosome 9p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465512 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50083
Approved symbol	MIR6851
Name	microRNA 6851
Location	9p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6851
Ensembl gene	ENSG00000275651
Ensembl biotype	miRNA
Entrez	102465512
RNAcentral	URS000075EB65 — ncRNA, 67 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000617060

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000617060 — 1 exons

Exon	Start	End
ENSE00003721745	33467869	33467935

Expression profiles

Bgee: expression breadth ubiquitous, 103 present calls, max score 91.13.

Top tissues by expression

103 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	91.13	gold quality
skeletal muscle tissue	UBERON:0001134	88.99	gold quality
adrenal tissue	UBERON:0018303	84.37	gold quality
vermiform appendix	UBERON:0001154	84.09	gold quality
bone marrow	UBERON:0002371	80.93	gold quality
blood	UBERON:0000178	77.09	gold quality
lymph node	UBERON:0000029	76.91	gold quality
monocyte	CL:0000576	76.64	gold quality
muscle of leg	UBERON:0001383	75.53	gold quality
granulocyte	CL:0000094	75.48	gold quality
placenta	UBERON:0001987	75.31	gold quality
gastrocnemius	UBERON:0001388	74.85	gold quality
descending thoracic aorta	UBERON:0002345	73.72	gold quality
smooth muscle tissue	UBERON:0001135	73.12	gold quality
urinary bladder	UBERON:0001255	72.50	gold quality
right atrium auricular region	UBERON:0006631	72.48	gold quality
heart left ventricle	UBERON:0002084	72.30	gold quality
stomach	UBERON:0000945	72.11	gold quality
liver	UBERON:0002107	72.05	gold quality
fundus of stomach	UBERON:0001160	71.93	gold quality
heart	UBERON:0000948	71.91	gold quality
right lobe of liver	UBERON:0001114	71.79	gold quality
kidney	UBERON:0002113	71.51	gold quality
prefrontal cortex	UBERON:0000451	71.27	gold quality
islet of Langerhans	UBERON:0000006	71.14	gold quality
endometrium	UBERON:0001295	70.87	gold quality
body of stomach	UBERON:0001161	70.60	gold quality
body of pancreas	UBERON:0001150	70.31	gold quality
endocervix	UBERON:0000458	70.27	gold quality
adult mammalian kidney	UBERON:0000082	70.18	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.07

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.