MIR6852

Summary

MIR6852 (microRNA 6852, HGNC:49993) is a microRNA gene on chromosome 9p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465513 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49993
Approved symbol	MIR6852
Name	microRNA 6852
Location	9p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6852
Ensembl gene	ENSG00000284195
Ensembl biotype	miRNA
Entrez	102465513
RNAcentral	URS000075D075 — ncRNA, 66 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000621699

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000621699 — 1 exons

Exon	Start	End
ENSE00003751276	35710676	35710741

Expression profiles

Bgee: expression breadth broad, 67 present calls, max score 80.46.

Top tissues by expression

67 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	80.46	gold quality
adrenal tissue	UBERON:0018303	78.72	gold quality
blood	UBERON:0000178	76.52	gold quality
gastrocnemius	UBERON:0001388	72.86	gold quality
rectum	UBERON:0001052	70.42	gold quality
stomach	UBERON:0000945	70.05	gold quality
amygdala	UBERON:0001876	69.80	gold quality
right lobe of liver	UBERON:0001114	69.74	gold quality
liver	UBERON:0002107	69.71	gold quality
Ammon’s horn	UBERON:0001954	69.25	gold quality
body of stomach	UBERON:0001161	69.01	gold quality
corpus callosum	UBERON:0002336	68.98	gold quality
tibial artery	UBERON:0007610	68.77	gold quality
subcutaneous adipose tissue	UBERON:0002190	68.33	gold quality
thoracic aorta	UBERON:0001515	67.99	gold quality
lower esophagus	UBERON:0013473	67.99	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.99	gold quality
ascending aorta	UBERON:0001496	67.96	gold quality
fallopian tube	UBERON:0003889	67.88	gold quality
right atrium auricular region	UBERON:0006631	67.81	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.69	gold quality
heart left ventricle	UBERON:0002084	67.57	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.57	gold quality
body of pancreas	UBERON:0001150	67.08	gold quality
esophagus	UBERON:0001043	67.07	gold quality
granulocyte	CL:0000094	66.93	gold quality
left ovary	UBERON:0002119	66.50	gold quality
endometrium	UBERON:0001295	66.43	gold quality
transverse colon	UBERON:0001157	66.37	gold quality
substantia nigra	UBERON:0002038	66.22	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.