MIR6853

Summary

MIR6853 (microRNA 6853, HGNC:49945) is a microRNA gene on chromosome 9p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466201 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49945
Approved symbol	MIR6853
Name	microRNA 6853
Location	9p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6853
Ensembl gene	ENSG00000273945
Ensembl biotype	miRNA
Entrez	102466201
RNAcentral	URS000075DB84 — miRNA, 74 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000619642

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000619642 — 1 exons

Exon	Start	End
ENSE00003738334	35732922	35732995

Expression profiles

Bgee: expression breadth broad, 39 present calls, max score 78.32.

Top tissues by expression

39 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	78.32	gold quality
blood	UBERON:0000178	77.05	gold quality
stomach	UBERON:0000945	74.49	gold quality
gastrocnemius	UBERON:0001388	74.31	gold quality
right atrium auricular region	UBERON:0006631	72.47	gold quality
adult mammalian kidney	UBERON:0000082	71.03	gold quality
muscle layer of sigmoid colon	UBERON:0035805	69.31	gold quality
skin of abdomen	UBERON:0001416	67.82	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.80	gold quality
Ammon’s horn	UBERON:0001954	67.64	gold quality
substantia nigra	UBERON:0002038	66.79	gold quality
body of uterus	UBERON:0009853	66.63	gold quality
ascending aorta	UBERON:0001496	66.45	gold quality
skin of leg	UBERON:0001511	66.42	gold quality
left adrenal gland	UBERON:0001234	65.93	gold quality
tibial artery	UBERON:0007610	65.86	gold quality
transverse colon	UBERON:0001157	65.43	gold quality
left adrenal gland cortex	UBERON:0035825	65.13	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.80	gold quality
omental fat pad	UBERON:0010414	63.71	gold quality
esophagus mucosa	UBERON:0002469	62.49	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	62.49	gold quality
small intestine Peyer’s patch	UBERON:0003454	61.70	gold quality
right hemisphere of cerebellum	UBERON:0014890	60.83	gold quality
Brodmann (1909) area 9	UBERON:0013540	60.75	gold quality
thoracic mammary gland	UBERON:0005200	60.63	gold quality
adenohypophysis	UBERON:0002196	59.62	gold quality
left lobe of thyroid gland	UBERON:0001120	59.57	gold quality
caudate nucleus	UBERON:0001873	59.30	gold quality
pituitary gland	UBERON:0000007	59.18	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.08

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.