MIR6854

Summary

MIR6854 (microRNA 6854, HGNC:50084) is a microRNA gene on chromosome 9q22.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465514 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50084
Approved symbol	MIR6854
Name	microRNA 6854
Location	9q22.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6854
Ensembl gene	ENSG00000278412
Ensembl biotype	miRNA
Entrez	102465514
RNAcentral	URS000075DB59 — ncRNA, 69 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000614935

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000614935 — 1 exons

Exon	Start	End
ENSE00003718685	98229149	98229217

Expression profiles

Bgee: expression breadth broad, 34 present calls, max score 81.90.

Top tissues by expression

34 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
putamen	UBERON:0001874	81.90	gold quality
calcaneal tendon	UBERON:0003701	80.28	gold quality
right lobe of liver	UBERON:0001114	79.35	gold quality
blood	UBERON:0000178	76.44	gold quality
monocyte	CL:0000576	75.58	gold quality
gastrocnemius	UBERON:0001388	72.15	gold quality
body of pancreas	UBERON:0001150	70.65	gold quality
tibial artery	UBERON:0007610	70.34	gold quality
right frontal lobe	UBERON:0002810	68.60	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.98	gold quality
spleen	UBERON:0002106	66.31	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.31	gold quality
liver	UBERON:0002107	66.30	gold quality
upper lobe of left lung	UBERON:0008952	65.98	gold quality
intestine	UBERON:0000160	65.74	gold quality
left adrenal gland	UBERON:0001234	65.39	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.82	gold quality
ascending aorta	UBERON:0001496	64.44	gold quality
small intestine Peyer’s patch	UBERON:0003454	64.34	gold quality
skin of leg	UBERON:0001511	64.08	gold quality
left lobe of thyroid gland	UBERON:0001120	63.96	gold quality
skin of abdomen	UBERON:0001416	63.31	gold quality
transverse colon	UBERON:0001157	63.16	gold quality
thyroid gland	UBERON:0002046	62.82	gold quality
esophagus mucosa	UBERON:0002469	62.66	gold quality
minor salivary gland	UBERON:0001830	62.20	gold quality
vagina	UBERON:0000996	61.77	gold quality
omental fat pad	UBERON:0010414	61.67	gold quality
endocervix	UBERON:0000458	61.22	gold quality
tibial nerve	UBERON:0001323	61.11	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.28

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.