MIR6855

Summary

MIR6855 (microRNA 6855, HGNC:50061) is a microRNA gene on chromosome 9q34.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466750 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50061
Approved symbol	MIR6855
Name	microRNA 6855
Location	9q34.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6855
Ensembl gene	ENSG00000276124
Ensembl biotype	miRNA
Entrez	102466750
RNAcentral	URS0000759BC7 — ncRNA, 67 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000622178

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000622178 — 1 exons

Exon	Start	End
ENSE00003744495	129869605	129869671

Expression profiles

Bgee: expression breadth broad, 98 present calls, max score 97.27.

Top tissues by expression

98 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	97.27	gold quality
skeletal muscle tissue	UBERON:0001134	89.72	gold quality
vermiform appendix	UBERON:0001154	84.19	gold quality
bone marrow	UBERON:0002371	81.92	gold quality
placenta	UBERON:0001987	79.18	gold quality
adrenal tissue	UBERON:0018303	77.96	gold quality
blood	UBERON:0000178	76.62	gold quality
muscle of leg	UBERON:0001383	75.33	gold quality
calcaneal tendon	UBERON:0003701	74.97	gold quality
gastrocnemius	UBERON:0001388	74.74	gold quality
monocyte	CL:0000576	73.56	gold quality
lymph node	UBERON:0000029	73.33	gold quality
heart left ventricle	UBERON:0002084	72.63	gold quality
fundus of stomach	UBERON:0001160	72.58	gold quality
right ovary	UBERON:0002118	72.48	gold quality
granulocyte	CL:0000094	72.43	gold quality
endometrium	UBERON:0001295	71.80	gold quality
tibial artery	UBERON:0007610	71.62	gold quality
popliteal artery	UBERON:0002250	71.56	gold quality
heart	UBERON:0000948	71.49	gold quality
ectocervix	UBERON:0012249	71.49	gold quality
islet of Langerhans	UBERON:0000006	71.12	gold quality
smooth muscle tissue	UBERON:0001135	70.83	gold quality
right atrium auricular region	UBERON:0006631	70.82	gold quality
thoracic aorta	UBERON:0001515	70.56	gold quality
ascending aorta	UBERON:0001496	70.55	gold quality
stomach	UBERON:0000945	70.48	gold quality
right adrenal gland	UBERON:0001233	70.48	gold quality
ovary	UBERON:0000992	70.46	gold quality
body of pancreas	UBERON:0001150	70.28	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.22

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The role of the redox/miR-6855-3p/PRDX5A axis in reversing SLUG-mediated BRCA2 silencing in breast cancer cells. (PMID:31987042)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.