MIR6856

Summary

MIR6856 (microRNA 6856, HGNC:50242) is a microRNA gene on chromosome 9q34.12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465515 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50242
Approved symbol	MIR6856
Name	microRNA 6856
Location	9q34.12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6856
Ensembl gene	ENSG00000277713
Ensembl biotype	miRNA
Entrez	102465515
RNAcentral	URS000075CA9A — ncRNA, 67 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000613330

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000613330 — 1 exons

Exon	Start	End
ENSE00003718221	130626297	130626363

Expression profiles

Bgee: expression breadth broad, 92 present calls, max score 82.01.

Top tissues by expression

92 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.01	gold quality
adrenal tissue	UBERON:0018303	80.76	gold quality
bone marrow	UBERON:0002371	80.29	gold quality
blood	UBERON:0000178	79.07	gold quality
prefrontal cortex	UBERON:0000451	76.29	gold quality
monocyte	CL:0000576	75.87	gold quality
muscle of leg	UBERON:0001383	74.31	gold quality
gastrocnemius	UBERON:0001388	73.92	gold quality
calcaneal tendon	UBERON:0003701	72.99	gold quality
liver	UBERON:0002107	72.73	gold quality
urinary bladder	UBERON:0001255	72.50	gold quality
islet of Langerhans	UBERON:0000006	71.71	gold quality
heart left ventricle	UBERON:0002084	71.28	gold quality
right lobe of liver	UBERON:0001114	70.72	gold quality
heart	UBERON:0000948	70.53	gold quality
body of pancreas	UBERON:0001150	70.00	gold quality
popliteal artery	UBERON:0002250	69.92	gold quality
tibial artery	UBERON:0007610	69.87	gold quality
left coronary artery	UBERON:0001626	69.85	gold quality
stomach	UBERON:0000945	69.68	gold quality
body of stomach	UBERON:0001161	69.15	gold quality
ovary	UBERON:0000992	68.92	gold quality
right atrium auricular region	UBERON:0006631	68.87	gold quality
left ovary	UBERON:0002119	68.58	gold quality
endocervix	UBERON:0000458	68.56	gold quality
lower esophagus	UBERON:0013473	68.41	gold quality
skin of abdomen	UBERON:0001416	68.31	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.30	gold quality
colon	UBERON:0001155	68.00	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.06

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.