MIR6857

Summary

MIR6857 (microRNA 6857, HGNC:50263) is a microRNA gene on chromosome Xp11.22.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465516 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50263
Approved symbol	MIR6857
Name	microRNA 6857
Location	Xp11.22
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6857
Ensembl gene	ENSG00000278204
Ensembl biotype	miRNA
Entrez	102465516
RNAcentral	URS000075E5E4 — miRNA, 93 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000613267

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000613267 — 1 exons

Exon	Start	End
ENSE00003744432	53405673	53405765

Expression profiles

Bgee: expression breadth broad, 17 present calls, max score 77.72.

Top tissues by expression

17 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	77.72	gold quality
adult mammalian kidney	UBERON:0000082	71.86	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.44	gold quality
amygdala	UBERON:0001876	67.13	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.58	gold quality
right frontal lobe	UBERON:0002810	64.42	gold quality
liver	UBERON:0002107	63.90	gold quality
intestine	UBERON:0000160	63.25	gold quality
esophagus mucosa	UBERON:0002469	62.95	gold quality
skin of leg	UBERON:0001511	62.87	gold quality
right hemisphere of cerebellum	UBERON:0014890	61.88	gold quality
left ovary	UBERON:0002119	58.75	gold quality
skin of abdomen	UBERON:0001416	58.50	gold quality
prostate gland	UBERON:0002367	55.49	gold quality
spleen	UBERON:0002106	53.36	gold quality
colon	UBERON:0001155	49.60	gold quality
left testis	UBERON:0004533	43.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.