MIR6858

Summary

MIR6858 (microRNA 6858, HGNC:50250) is a microRNA gene on chromosome Xq28.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465517 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50250
Approved symbol	MIR6858
Name	microRNA 6858
Location	Xq28
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6858
Ensembl gene	ENSG00000276350
Ensembl biotype	miRNA
Entrez	102465517
RNAcentral	URS0000759E7D — miRNA, 67 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000620733

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000620733 — 1 exons

Exon	Start	End
ENSE00003735566	154450320	154450386

Expression profiles

Bgee: expression breadth broad, 89 present calls, max score 84.19.

Top tissues by expression

89 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	84.19	gold quality
bone marrow	UBERON:0002371	81.76	gold quality
adrenal tissue	UBERON:0018303	78.60	gold quality
prefrontal cortex	UBERON:0000451	76.29	gold quality
granulocyte	CL:0000094	75.48	gold quality
placenta	UBERON:0001987	75.31	gold quality
blood	UBERON:0000178	74.61	gold quality
endocervix	UBERON:0000458	74.49	gold quality
muscle of leg	UBERON:0001383	74.35	gold quality
monocyte	CL:0000576	73.50	gold quality
gastrocnemius	UBERON:0001388	73.24	gold quality
endometrium	UBERON:0001295	72.96	gold quality
left adrenal gland cortex	UBERON:0035825	71.02	gold quality
heart left ventricle	UBERON:0002084	71.01	gold quality
adrenal gland	UBERON:0002369	70.86	gold quality
body of stomach	UBERON:0001161	70.82	gold quality
stomach	UBERON:0000945	70.57	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	70.54	gold quality
right lobe of liver	UBERON:0001114	70.32	gold quality
left adrenal gland	UBERON:0001234	70.17	gold quality
amygdala	UBERON:0001876	70.01	gold quality
heart	UBERON:0000948	69.75	gold quality
putamen	UBERON:0001874	69.28	gold quality
right adrenal gland cortex	UBERON:0035827	69.25	gold quality
right adrenal gland	UBERON:0001233	68.91	gold quality
body of pancreas	UBERON:0001150	68.87	gold quality
right atrium auricular region	UBERON:0006631	68.80	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.23	gold quality
ascending aorta	UBERON:0001496	68.20	gold quality
popliteal artery	UBERON:0002250	67.86	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.23

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• miR-6858 plays a key role in the process of melatonin inhibition of the malignant biological behavior of glioma. (PMID:33863521)
• METTL14-upregulated miR-6858 triggers cell apoptosis in keratinocytes of oral lichen planus through decreasing GSDMC. (PMID:37741915)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.