MIR6859-2

Summary

MIR6859-2 (microRNA 6859-2, HGNC:49954) is a microRNA gene on chromosome 1p36.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465909 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49954
Approved symbol	MIR6859-2
Name	microRNA 6859-2
Location	1p36.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6859-2
Ensembl gene	ENSG00000273874
Ensembl biotype	miRNA
Entrez	102465909
RNAcentral	URS000075A3E2 — miRNA, 68 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000612080

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000612080 — 1 exons

Exon	Start	End
ENSE00003737837	187891	187958

Expression profiles

Bgee: expression breadth ubiquitous, 108 present calls, max score 80.54.

Top tissues by expression

108 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	80.54	gold quality
sural nerve	UBERON:0015488	79.43	gold quality
duodenum	UBERON:0002114	77.60	gold quality
vermiform appendix	UBERON:0001154	77.06	gold quality
placenta	UBERON:0001987	71.19	gold quality
lymph node	UBERON:0000029	70.46	gold quality
adrenal tissue	UBERON:0018303	70.12	gold quality
apex of heart	UBERON:0002098	67.76	gold quality
blood	UBERON:0000178	67.72	gold quality
bone marrow	UBERON:0002371	67.68	gold quality
muscle of leg	UBERON:0001383	66.11	gold quality
urinary bladder	UBERON:0001255	65.31	gold quality
gastrocnemius	UBERON:0001388	64.76	gold quality
prefrontal cortex	UBERON:0000451	64.64	gold quality
right uterine tube	UBERON:0001302	63.93	gold quality
smooth muscle tissue	UBERON:0001135	63.36	gold quality
heart left ventricle	UBERON:0002084	63.25	gold quality
islet of Langerhans	UBERON:0000006	62.32	gold quality
endometrium	UBERON:0001295	62.11	gold quality
right lobe of thyroid gland	UBERON:0001119	61.47	gold quality
heart	UBERON:0000948	61.46	gold quality
body of stomach	UBERON:0001161	61.07	gold quality
stomach	UBERON:0000945	60.99	gold quality
left uterine tube	UBERON:0001303	60.72	gold quality
fundus of stomach	UBERON:0001160	60.53	gold quality
adrenal gland	UBERON:0002369	60.44	gold quality
adult mammalian kidney	UBERON:0000082	60.19	gold quality
right atrium auricular region	UBERON:0006631	60.18	gold quality
pancreas	UBERON:0001264	59.83	gold quality
liver	UBERON:0002107	59.80	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.27

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (3): MIR6859-3 (ENSG00000275449), MIR6859-1 (ENSG00000278267), MIR6859-4 (ENSG00000278739)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.