MIR6860

Summary

MIR6860 (microRNA 6860, HGNC:50086) is a microRNA gene on chromosome 11q13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465518 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50086
Approved symbol	MIR6860
Name	microRNA 6860
Location	11q13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6860
Ensembl gene	ENSG00000283326
Ensembl biotype	miRNA
Entrez	102465518
RNAcentral	URS000075A7C9 — ncRNA, 66 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000635882

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000635882 — 1 exons

Exon	Start	End
ENSE00003801055	67045643	67045708

Expression profiles

Bgee: expression breadth broad, 31 present calls, max score 80.18.

Top tissues by expression

31 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	80.18	gold quality
right lobe of liver	UBERON:0001114	72.92	gold quality
omental fat pad	UBERON:0010414	72.82	gold quality
left adrenal gland cortex	UBERON:0035825	71.14	gold quality
left adrenal gland	UBERON:0001234	70.56	gold quality
minor salivary gland	UBERON:0001830	68.10	gold quality
left coronary artery	UBERON:0001626	67.20	gold quality
skin of leg	UBERON:0001511	67.19	gold quality
amygdala	UBERON:0001876	66.51	gold quality
anterior cingulate cortex	UBERON:0009835	66.15	gold quality
ascending aorta	UBERON:0001496	66.05	gold quality
Ammon’s horn	UBERON:0001954	65.54	gold quality
heart left ventricle	UBERON:0002084	65.49	gold quality
hypothalamus	UBERON:0001898	65.28	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.90	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	64.83	gold quality
blood	UBERON:0000178	64.71	gold quality
right frontal lobe	UBERON:0002810	64.63	gold quality
prostate gland	UBERON:0002367	63.92	gold quality
cerebellar hemisphere	UBERON:0002245	62.91	gold quality
spleen	UBERON:0002106	62.80	gold quality
right hemisphere of cerebellum	UBERON:0014890	62.79	gold quality
putamen	UBERON:0001874	62.78	gold quality
multicellular organism	UBERON:0000468	62.75	gold quality
nucleus accumbens	UBERON:0001882	62.18	gold quality
Brodmann (1909) area 9	UBERON:0013540	61.75	gold quality
skin of abdomen	UBERON:0001416	58.69	gold quality
pituitary gland	UBERON:0000007	58.29	gold quality
esophagus mucosa	UBERON:0002469	56.27	gold quality
right testis	UBERON:0004534	48.13	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.21

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.