MIR6861

Summary

MIR6861 (microRNA 6861, HGNC:50129) is a microRNA gene on chromosome 12q24.13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465519 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50129
Approved symbol	MIR6861
Name	microRNA 6861
Location	12q24.13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6861
Ensembl gene	ENSG00000283793
Ensembl biotype	miRNA
Entrez	102465519
RNAcentral	URS000075B892 — ncRNA, 64 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000618657

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000618657 — 1 exons

Exon	Start	End
ENSE00003712608	112163258	112163321

Expression profiles

Bgee: expression breadth broad, 58 present calls, max score 95.07.

Top tissues by expression

58 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	95.07	gold quality
bone marrow	UBERON:0002371	78.55	gold quality
blood	UBERON:0000178	78.51	gold quality
muscle of leg	UBERON:0001383	76.82	gold quality
monocyte	CL:0000576	75.31	gold quality
liver	UBERON:0002107	74.89	gold quality
gastrocnemius	UBERON:0001388	74.63	gold quality
heart left ventricle	UBERON:0002084	73.82	gold quality
right lobe of liver	UBERON:0001114	71.93	gold quality
body of pancreas	UBERON:0001150	70.44	gold quality
amygdala	UBERON:0001876	70.18	gold quality
Ammon’s horn	UBERON:0001954	69.47	gold quality
putamen	UBERON:0001874	68.75	gold quality
body of stomach	UBERON:0001161	67.60	gold quality
tibial artery	UBERON:0007610	67.12	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.03	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.53	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.40	gold quality
ascending aorta	UBERON:0001496	66.31	gold quality
esophagus mucosa	UBERON:0002469	66.28	gold quality
left coronary artery	UBERON:0001626	66.13	gold quality
substantia nigra	UBERON:0002038	66.08	gold quality
small intestine Peyer’s patch	UBERON:0003454	65.82	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	65.61	gold quality
transverse colon	UBERON:0001157	65.53	gold quality
right frontal lobe	UBERON:0002810	65.52	gold quality
caudate nucleus	UBERON:0001873	65.43	gold quality
tibial nerve	UBERON:0001323	65.31	gold quality
skin of abdomen	UBERON:0001416	65.15	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.57

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.