MIR6862-1

Summary

MIR6862-1 (microRNA 6862-1, HGNC:50052) is a microRNA gene on chromosome 16p12.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465520 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50052
Approved symbol	MIR6862-1
Name	microRNA 6862-1
Location	16p12.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6862-1
Ensembl gene	ENSG00000275429
Ensembl biotype	miRNA
Entrez	102465520
RNAcentral	URS000075DEBA — miRNA, 70 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000613016

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000613016 — 1 exons

Exon	Start	End
ENSE00003731329	28390982	28391051

Expression profiles

Bgee: expression breadth broad, 86 present calls, max score 81.04.

Top tissues by expression

86 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	81.04	gold quality
bone marrow	UBERON:0002371	74.84	gold quality
blood	UBERON:0000178	72.64	gold quality
muscle of leg	UBERON:0001383	68.41	gold quality
gastrocnemius	UBERON:0001388	67.19	gold quality
right uterine tube	UBERON:0001302	66.10	gold quality
islet of Langerhans	UBERON:0000006	66.01	gold quality
heart left ventricle	UBERON:0002084	65.51	gold quality
descending thoracic aorta	UBERON:0002345	65.03	gold quality
myometrium	UBERON:0001296	64.86	gold quality
popliteal artery	UBERON:0002250	64.41	gold quality
body of stomach	UBERON:0001161	64.34	gold quality
body of uterus	UBERON:0009853	64.11	gold quality
tibial artery	UBERON:0007610	64.08	gold quality
ascending aorta	UBERON:0001496	63.87	gold quality
thoracic aorta	UBERON:0001515	63.85	gold quality
heart	UBERON:0000948	63.71	gold quality
body of pancreas	UBERON:0001150	63.41	gold quality
stomach	UBERON:0000945	63.36	gold quality
right atrium auricular region	UBERON:0006631	62.58	gold quality
left adrenal gland cortex	UBERON:0035825	62.58	gold quality
endometrium	UBERON:0001295	62.24	gold quality
Ammon’s horn	UBERON:0001954	62.11	gold quality
right lobe of liver	UBERON:0001114	61.99	gold quality
liver	UBERON:0002107	61.98	gold quality
left ovary	UBERON:0002119	61.63	gold quality
kidney	UBERON:0002113	61.32	gold quality
hypothalamus	UBERON:0001898	61.22	gold quality
endocervix	UBERON:0000458	61.10	gold quality
anterior cingulate cortex	UBERON:0009835	60.94	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.39

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• MicroRNA-6862 inhibition elevates sphingosine kinase 1 and protects neuronal cells from MPP(+)-induced apoptosis. (PMID:33414358)

Cross-species orthologs

0 orthologs

Paralogs (1): MIR6862-2 (ENSG00000278340)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.