MIR6863

Summary

MIR6863 (microRNA 6863, HGNC:49942) is a microRNA gene on chromosome 16q13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466752 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49942
Approved symbol	MIR6863
Name	microRNA 6863
Location	16q13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6863
Ensembl gene	ENSG00000283471
Ensembl biotype	miRNA
Entrez	102466752
RNAcentral	URS000075A1A0 — miRNA, 90 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636112

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636112 — 1 exons

Exon	Start	End
ENSE00003792301	56904264	56904353

Expression profiles

Bgee: expression breadth broad, 19 present calls, max score 79.79.

Top tissues by expression

19 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	79.79	gold quality
adult mammalian kidney	UBERON:0000082	78.06	gold quality
kidney	UBERON:0002113	76.41	gold quality
stomach	UBERON:0000945	74.74	gold quality
endometrium	UBERON:0001295	73.95	gold quality
body of stomach	UBERON:0001161	70.74	gold quality
lung	UBERON:0002048	70.49	gold quality
body of pancreas	UBERON:0001150	69.99	gold quality
omental fat pad	UBERON:0010414	66.35	gold quality
right frontal lobe	UBERON:0002810	65.29	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.62	gold quality
transverse colon	UBERON:0001157	64.59	gold quality
tibial nerve	UBERON:0001323	64.39	gold quality
metanephros cortex	UBERON:0010533	63.95	gold quality
ascending aorta	UBERON:0001496	63.59	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.21	gold quality
nucleus accumbens	UBERON:0001882	63.17	gold quality
left lobe of thyroid gland	UBERON:0001120	52.96	gold quality
left testis	UBERON:0004533	34.24	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• We found that the three protein-coding genes functionally interact with targets of their intronic miRNAs, i.e., miR-3182, miR-6863, and miR-5582, in a tissue-specific pattern. (PMID:31464655)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.