MIR6864

Summary

MIR6864 (microRNA 6864, HGNC:50226) is a microRNA gene on chromosome 17p13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465521 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50226
Approved symbol	MIR6864
Name	microRNA 6864
Location	17p13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6864
Ensembl gene	ENSG00000274300
Ensembl biotype	miRNA
Entrez	102465521
RNAcentral	URS000075DA29 — miRNA, 70 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000617935

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000617935 — 1 exons

Exon	Start	End
ENSE00003715431	4969702	4969771

Expression profiles

Bgee: expression breadth ubiquitous, 105 present calls, max score 93.65.

Top tissues by expression

105 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	93.65	gold quality
skeletal muscle tissue	UBERON:0001134	91.34	gold quality
duodenum	UBERON:0002114	84.50	gold quality
adrenal tissue	UBERON:0018303	83.99	gold quality
lymph node	UBERON:0000029	83.42	gold quality
vermiform appendix	UBERON:0001154	83.24	gold quality
tonsil	UBERON:0002372	82.39	gold quality
bone marrow	UBERON:0002371	80.60	gold quality
blood	UBERON:0000178	78.88	gold quality
endometrium	UBERON:0001295	76.91	gold quality
right adrenal gland cortex	UBERON:0035827	76.57	gold quality
monocyte	CL:0000576	76.16	gold quality
liver	UBERON:0002107	74.94	gold quality
granulocyte	CL:0000094	74.92	gold quality
muscle of leg	UBERON:0001383	74.92	gold quality
right lobe of liver	UBERON:0001114	74.76	gold quality
right hemisphere of cerebellum	UBERON:0014890	74.62	gold quality
mucosa of transverse colon	UBERON:0004991	74.56	gold quality
calcaneal tendon	UBERON:0003701	74.12	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	73.83	gold quality
stomach	UBERON:0000945	73.58	gold quality
right adrenal gland	UBERON:0001233	73.55	gold quality
gastrocnemius	UBERON:0001388	73.41	gold quality
cerebellar hemisphere	UBERON:0002245	73.32	gold quality
adrenal gland	UBERON:0002369	73.18	gold quality
islet of Langerhans	UBERON:0000006	73.10	gold quality
body of stomach	UBERON:0001161	72.97	gold quality
right atrium auricular region	UBERON:0006631	72.72	gold quality
kidney	UBERON:0002113	72.46	gold quality
lower esophagus mucosa	UBERON:0035834	72.31	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.08

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.