MIR6865

Summary

MIR6865 (microRNA 6865, HGNC:50182) is a microRNA gene on chromosome 17p13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465522 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50182
Approved symbol	MIR6865
Name	microRNA 6865
Location	17p13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6865
Ensembl gene	ENSG00000278517
Ensembl biotype	miRNA
Entrez	102465522
RNAcentral	URS000075DFA1 — ncRNA, 65 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000614295

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000614295 — 1 exons

Exon	Start	End
ENSE00003717529	4970086	4970150

Expression profiles

Bgee: expression breadth ubiquitous, 104 present calls, max score 90.98.

Top tissues by expression

104 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	90.98	gold quality
prefrontal cortex	UBERON:0000451	85.11	gold quality
right hemisphere of cerebellum	UBERON:0014890	83.15	gold quality
cerebellar hemisphere	UBERON:0002245	81.54	gold quality
adrenal tissue	UBERON:0018303	81.43	gold quality
bone marrow	UBERON:0002371	79.03	gold quality
blood	UBERON:0000178	78.20	gold quality
monocyte	CL:0000576	78.19	gold quality
granulocyte	CL:0000094	77.90	gold quality
smooth muscle tissue	UBERON:0001135	77.18	gold quality
muscle of leg	UBERON:0001383	76.08	gold quality
placenta	UBERON:0001987	75.90	gold quality
gastrocnemius	UBERON:0001388	75.78	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	74.47	gold quality
mucosa of stomach	UBERON:0001199	74.38	gold quality
endometrium	UBERON:0001295	73.73	gold quality
islet of Langerhans	UBERON:0000006	73.50	gold quality
urinary bladder	UBERON:0001255	73.31	gold quality
right coronary artery	UBERON:0001625	73.20	gold quality
body of uterus	UBERON:0009853	73.19	gold quality
descending thoracic aorta	UBERON:0002345	72.81	gold quality
popliteal artery	UBERON:0002250	72.77	gold quality
tibial artery	UBERON:0007610	72.73	gold quality
body of pancreas	UBERON:0001150	72.33	gold quality
brain	UBERON:0000955	72.21	gold quality
left adrenal gland cortex	UBERON:0035825	72.05	gold quality
heart left ventricle	UBERON:0002084	71.94	gold quality
heart	UBERON:0000948	71.71	gold quality
thoracic aorta	UBERON:0001515	71.68	gold quality
myometrium	UBERON:0001296	71.66	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.58

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.