MIR6867

Summary

MIR6867 (microRNA 6867, HGNC:50134) is a microRNA gene on chromosome 17q21.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465523 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50134
Approved symbol	MIR6867
Name	microRNA 6867
Location	17q21.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6867
Ensembl gene	ENSG00000274621
Ensembl biotype	miRNA
Entrez	102465523
RNAcentral	URS000075B8A6 — miRNA, 67 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000610636

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000610636 — 1 exons

Exon	Start	End
ENSE00003750961	40193597	40193663

Expression profiles

Bgee: expression breadth ubiquitous, 102 present calls, max score 95.55.

Top tissues by expression

102 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	95.55	gold quality
skin of leg	UBERON:0001511	92.67	gold quality
zone of skin	UBERON:0000014	91.83	gold quality
skin of abdomen	UBERON:0001416	90.92	gold quality
vagina	UBERON:0000996	89.76	gold quality
lymph node	UBERON:0000029	89.32	gold quality
esophagus mucosa	UBERON:0002469	89.07	gold quality
mucosa of transverse colon	UBERON:0004991	87.94	gold quality
urinary bladder	UBERON:0001255	85.05	gold quality
duodenum	UBERON:0002114	84.89	gold quality
esophagus	UBERON:0001043	84.19	gold quality
transverse colon	UBERON:0001157	81.08	gold quality
ectocervix	UBERON:0012249	79.35	gold quality
colon	UBERON:0001155	77.76	gold quality
right frontal lobe	UBERON:0002810	77.08	gold quality
bone marrow	UBERON:0002371	77.01	gold quality
frontal cortex	UBERON:0001870	76.96	gold quality
endocervix	UBERON:0000458	76.74	gold quality
tonsil	UBERON:0002372	76.74	gold quality
right hemisphere of cerebellum	UBERON:0014890	76.56	gold quality
intestine	UBERON:0000160	76.49	gold quality
kidney	UBERON:0002113	75.30	gold quality
cerebellar hemisphere	UBERON:0002245	75.13	gold quality
hypothalamus	UBERON:0001898	74.82	gold quality
cerebral cortex	UBERON:0000956	74.63	gold quality
nucleus accumbens	UBERON:0001882	74.61	gold quality
blood	UBERON:0000178	74.47	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	74.36	gold quality
Brodmann (1909) area 9	UBERON:0013540	74.36	gold quality
muscle of leg	UBERON:0001383	74.14	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.34

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• lncRNA ARAP1-AS1 enhances proliferation and impairs apoptosis of lymphoma cells by sponging miR-6867-5p. (PMID:37599524)
• The human PTGR1 gene expression is controlled by TE-derived Z-DNA forming sequence cooperating with miR-6867-5p. (PMID:38413664)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.