MIR6868

Summary

MIR6868 (microRNA 6868, HGNC:50096) is a microRNA gene on chromosome 17q25.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466753 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50096
Approved symbol	MIR6868
Name	microRNA 6868
Location	17q25.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6868
Ensembl gene	ENSG00000275360
Ensembl biotype	miRNA
Entrez	102466753
RNAcentral	URS000075EE35 — miRNA, 58 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000611215

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000611215 — 1 exons

Exon	Start	End
ENSE00003738288	76098019	76098076

Expression profiles

Bgee: expression breadth broad, 21 present calls, max score 80.99.

Top tissues by expression

21 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	80.99	gold quality
prefrontal cortex	UBERON:0000451	78.86	gold quality
heart	UBERON:0000948	77.61	gold quality
blood	UBERON:0000178	74.12	gold quality
endometrium	UBERON:0001295	70.10	gold quality
Brodmann (1909) area 9	UBERON:0013540	69.61	gold quality
muscle layer of sigmoid colon	UBERON:0035805	69.55	gold quality
transverse colon	UBERON:0001157	68.52	gold quality
heart left ventricle	UBERON:0002084	68.50	gold quality
left lobe of thyroid gland	UBERON:0001120	66.88	gold quality
skin of leg	UBERON:0001511	66.36	gold quality
cerebellar hemisphere	UBERON:0002245	66.19	gold quality
tibial nerve	UBERON:0001323	64.92	gold quality
minor salivary gland	UBERON:0001830	62.87	gold quality
vagina	UBERON:0000996	62.69	gold quality
colon	UBERON:0001155	62.15	gold quality
anterior cingulate cortex	UBERON:0009835	61.19	gold quality
spleen	UBERON:0002106	60.75	gold quality
skin of abdomen	UBERON:0001416	59.42	gold quality
left testis	UBERON:0004533	43.76	gold quality
corpus callosum	UBERON:0002336	39.57	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.06

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Data identify miR-6868-5p as a novel determinant of FOXM1 expression and establish a miR-6868-5p/FOXM1 regulatory circuit for CRC angiogenesis. (PMID:30486864)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.